epitope mapping near the C-terminus of BCAM of human origin
recommended for detection of mature LU and BCAM precursor of mouse, rat and human origin by ELISA; also reactive with additional species, including equine and porcine
BCAM Background Information Cell adhesion molecules (CAMs) influence cell growth, differentiation, embryogenesis, immune response and cancer metastasis by networking information from the extracellular matrix to the cell. Regulation of neuronal synaptic adhesion by CAMs has proven important for learning and memory. Proper embryonic morphogenic development is also heavily dependent on the regulation of cell adhesion molecules. Mutation of CAM genes has been linked to several forms of cancer, effecting tumor growth and metastasis. Lutheran blood group glycoprotein, also designated B-CAM cell surface glycoprotein or auberger B antigen, plays a role in intracellular signaling. It is a widely expressed protein but the highest level of expression is in pancreas tissue.
