Lsh Background Information The SNF2 family of helicases are thought to act as transcriptional regulators by their ability to alter the structure of chromatin. One such member, Lymphoid-Specific Helicase (Lsh, also designated Hells for lymphoid-specific DNA helicase), is highly expressed in lymphoid precursor cells in adult animals and is required for the proliferation of peripheral T lymphocytes. Lsh is also expressed in fetal liver and more abundantly in fetal thymus. Lsh protein shows substantial homology to other members of the SNF2 family that are involved in chromatin remodeling and transcription, however does not show similarity to members involved in DNA repair or recombination. The similarity of Lsh to another SNF2 homolog, Mi-2, which functions as a transcriptional silencer in chromatin remodeling, suggests that Lsh may participate in chromatin repression to regulate transcription, rather than chromatin “opening”.
Lsh (H-4) Product Citations
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Lsh (H-4)
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Lsh (H-4): sc-46665. Western blot analysis of Lsh expression in JM1 (A), CCRF-CEM (B) and BW5147 (C) whole cell lysates.
Lsh (H-4): sc-46665. Western blot analysis of Lsh expression in CCRF-CEM whole cell lysate.
Lsh (H-4): sc-46665. Immunoperoxidase staining of formalin fixed, paraffin-embedded human lymph node tissue showing nuclear staining of follicle cells. Kindly provided by The Swedish Human Protein Atlas (HPA) program.
Lsh (H-4): sc-46665. Western blot analysis of Lsh expression in non-transfected 293T: sc-117752 (A), human Lsh transfected 293T: sc-177484 (B) and JM1 (C) whole cell lysates.
