TAF II p250 (N-12) Antibody: sc-46649

TAF II p250 Background Information
TFIID is a general transcription factor which initiates pre-initiation complex assembly through direct interaction with the TATA promoter element. It is a multi-subunit complex consisting of a small TATA-binding polypeptide and other TBP-associated factors (TAFs). Although native TFIID can mediate both activator-independent (basal) and activator-dependent transcription in reconstituted systems, TBP can mediate only basal transcription. The largest subunit (TAF) of TFIID is a protein designated TAF II p250. Of interest, TAF II p250 has been cloned and shown to be identical to CCG1, a nuclear DNA-binding protein known to be important for cell cycle progression. This part of TAF II p250 may serve a specific function in activation of a subset of genes important for cell cycle progression.