epitope mapping within an N-terminal cytoplasmic domain of Vangl1 of human origin
recommended for detection of Vangl1 of mouse and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine and bovine
Vangl1 Background Information The Vang family of proteins are integral membrane proteins that are homologues of the Drosophila tissue polarity gene strabismus. The gene encoding for Van Gogh-like protein 1 (Vangl1), also designated Strabismus 2 (STB2), localizes to human chromosome 1p11-p13.1. Van Gogh-like protein 2 (Vangl2), also designated Strabismus 1 (STB1), localizes to chromosome 1q22-q23. Vangl1 is expressed primarily in testis and ovary, but is also expressed in gastric and pancreatic cancer. Vangl proteins play a key developmental role in establishing planar cell polarity (PCP) and in regulating convergent extension (CE) movements during embryogenesis. Vangl1 and Vangl2 are both downregulated in several cancer cell lines and primary tumors.
Vangl1 (E-19)
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Vangl1 (E-19): sc-46556. Western blot analysis of Vangl1 expression in non-transfected 293T: sc-117752 (A), human Vangl1 transfected 293T: sc-117119 (B) and HeLa (C) whole cell lysates.
