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home » Transcription Regulators » Replication Protein A Antibody / Replication Protein A Antibodies » RPA 14 kDa subunit (G-20): sc-46507

RPA 14 kDa subunit (G-20) Antibody: sc-46507

  |  Datasheet
  • goat polyclonal IgG, 200 µg/ml
  • epitope mapping near the N-terminus of RPA3 of mouse origin
  • recommended for detection of RPA 14 kDa subunit of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
  • blocking peptide, sc-46507 P
  • TransCruz reagent for Gel Supershift and ChIP applications, sc-46507 X, 200 µg/0.1 ml
 
Additional Replication Protein A Antibodies ...
 
Ordering Information
Recommended Support Products:
(click button of application of choice)
WB   IP   IF   Gel Shift   ChIP   siRNA  
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human RPA3 6119 7p21.3 NM_002947 P35244
 179837
Mouse Rpa3 68240 6 A1 Q9CQ71
 N/A
 
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 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
RPA 14 kDa subunit (G-20) sc-46507 200 µg/ml $279
RPA 14 kDa subunit (G-20) P sc-46507 P
(peptide)
 100 µg/0.5 ml $61
RPA 14 kDa subunit (G-20) X sc-46507 X 200 µg/0.1 ml $279
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
RPA 14 kDa subunit siRNA (h) sc-45476 10 µM $258
RPA 14 kDa subunit siRNA (m) sc-45713 10 µM $258
RPA 14kDa subunit siRNA (h)-PR sc-45476-PR 10 µM $23
RPA 14 kDa subunit siRNA (m)-PR sc-45713-PR 10 µM $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
RPA 14kDa subunit shRNA Plasmid (h) sc-45476-SH 20 µg $520
RPA 14 kDa subunit shRNA Plasmid (m) sc-45713-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
RPA 14kDa subunit siRNA shRNA (h) Lentiviral Particles sc-45476-V 200 µl $625
RPA 14 kDa subunit siRNA shRNA (m) Lentiviral Particles sc-45713-V 200 µl $625
 WB Positive Control Cell Lysates (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
NIH/3T3 nuclear extract sc-2138 1000 µg $143
HL-60 Whole Cell Lysate sc-2209 500 µg/200 µl $104

RPA 14 kDa subunit Background Information
The single-stranded-DNA-binding proteins (SSBs) are essential for DNA function in prokaryotic and eukaryotic cells, mitochondria, phages and viruses. Replication protein A (RPA), a highly conserved eukaryotic protein, is a heterotrimeric SSB that is composed of three subunits, designated RPA 14 kDa (also known as RPA3), RPA 32 kDa and RPA 70 kDa. Together, these subunits play an important role in DNA replication, recombination and repair. RPA is one of the major damage-recognition structures involved in the early stage of nucleotide excision repair and may play a role in telomere maintenance. The binding of human RPA (hRPA) to DNA involves molecular polarity, in which initial hRPA binding occurs on the 5’ side of a ssDNA substrate and then extends in the 3’ direction to create a stably bound hRPA. The RPA 14 kDa subunit localizes to the nucleus and is the smallest component of the RPA complex, functioning with the other subunits to regulate various aspects of DNA metabolism.
RPA 14 kDa subunit (G-20)
Click on image to enlarge
sc-46507
RPA 14 kDa subunit (G-20): sc-46507. Western blot analysis of RPA 14 kDa subunit expression in NIH/3T3 (A), HL-60 (B) and K-562 (C) whole cell lysates.
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