Date published: 2026-7-16

1-800-457-3801

SCBT Portrait Logo
Seach Input

HCN Antibodies

Santa Cruz Biotechnology features a diverse variety of HCN Antibodies for studying hyperpolarization-activated cyclic nucleotide-gated channels. HCN Antibodies are compatible with multiple research techniques, including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). HCN channels play a crucial role in regulating neuronal excitability and cardiac pacemaker activity, making them essential for understanding various physiological processes and potential pathologies. The function of HCN channels in controlling resting membrane potential and contributing to rhythmic activity highlights their significance in both the nervous and cardiovascular systems. Research into HCN channels has revealed their involvement in numerous neurological disorders and cardiac conditions. Understanding HCN channel distribution and expression patterns provides valuable information about cellular signaling pathways and potential therapeutic targets. Investigating HCN channels advances knowledge about membrane protein regulation and ion channel dynamics. Santa Cruz Biotechnology monoclonal antibodies for HCN channels enable researchers to advance scientific understanding of neural and cardiac function.

SEE ALSO...

HCN Antibodies

Empty Table HeaderProduct NameCATALOG #ISOTYPEEPITOPEAPPLICATIONSSpeciesCitationsRATING

HCN3 Antibody (TLL6C5)

sc-58621rat IgG1(m)WB, IPm, r, h, bovine and canine
1
(2)

HCN3 Antibody (A-3)

sc-393813mouse IgG1 κ625-774 (h)WB, IP, IF, ELISAh

new

(1)

HCN3 Antibody (B-12)

sc-365451mouse IgG1 κ757-778 (h)WB, IP, IF, ELISAh

new

(1)

HCN4 Antibody (SHG 1E5)

sc-58622rat IgG11048-1085 (h)WB, IP, IFm, r, h
6
(6)

HCN siRNA, shRNA Plasmid and shRNA Lentiviral Particle Gene Silencers

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

HCN1 siRNA (h)

sc-44341hGene SilencingN/A0
(0)

HCN1 shRNA Plasmid (h)

sc-44341-SHhGene SilencingPuromycin0
(0)

HCN1 shRNA (h) Lentiviral Particles

sc-44341-VhGene SilencingPuromycin0
(0)

HCN1 siRNA (m)

sc-145907mGene SilencingN/A0
(0)

HCN1 shRNA Plasmid (m)

sc-145907-SHmGene SilencingPuromycin0
(0)

HCN1 shRNA (m) Lentiviral Particles

sc-145907-VmGene SilencingPuromycin0
(0)

HCN1 siRNA (r)

sc-270291rGene SilencingN/A0
(0)

HCN1 shRNA Plasmid (r)

sc-270291-SHrGene SilencingPuromycin0
(0)

HCN1 shRNA (r) Lentiviral Particles

sc-270291-VrGene SilencingPuromycin0
(0)

HCN2 siRNA (h)

sc-35537hGene SilencingN/A0
(0)

HCN2 shRNA Plasmid (h)

sc-35537-SHhGene SilencingPuromycin0
(0)

HCN2 shRNA (h) Lentiviral Particles

sc-35537-VhGene SilencingPuromycin0
(0)

HCN2 siRNA (m)

sc-145908mGene SilencingN/A0
(0)

HCN2 shRNA Plasmid (m)

sc-145908-SHmGene SilencingPuromycin0
(0)

HCN2 shRNA (m) Lentiviral Particles

sc-145908-VmGene SilencingPuromycin0
(0)

HCN2 siRNA (r)

sc-270292rGene SilencingN/A0
(0)

HCN2 shRNA Plasmid (r)

sc-270292-SHrGene SilencingPuromycin0
(0)

HCN2 shRNA (r) Lentiviral Particles

sc-270292-VrGene SilencingPuromycin0
(0)

HCN3 siRNA (h)

sc-45651hGene SilencingN/A0
(0)

HCN3 shRNA Plasmid (h)

sc-45651-SHhGene SilencingPuromycin0
(0)

HCN3 shRNA (h) Lentiviral Particles

sc-45651-VhGene SilencingPuromycin0
(0)

HCN3 siRNA (m)

sc-45652mGene SilencingN/A0
(0)

HCN3 shRNA Plasmid (m)

sc-45652-SHmGene SilencingPuromycin0
(0)

HCN3 shRNA (m) Lentiviral Particles

sc-45652-VmGene SilencingPuromycin0
(0)

HCN3 siRNA (r)

sc-270293rGene SilencingN/A0
(0)

HCN3 shRNA Plasmid (r)

sc-270293-SHrGene SilencingPuromycin0
(0)

HCN3 shRNA (r) Lentiviral Particles

sc-270293-VrGene SilencingPuromycin0
(0)

HCN4 siRNA (h)

sc-42473hGene SilencingN/A0
(0)

HCN4 shRNA Plasmid (h)

sc-42473-SHhGene SilencingPuromycin0
(0)

HCN4 shRNA (h) Lentiviral Particles

sc-42473-VhGene SilencingPuromycin0
(0)

HCN4 siRNA (m)

sc-42474mGene SilencingN/A0
(0)

HCN4 shRNA Plasmid (m)

sc-42474-SHmGene SilencingPuromycin0
(0)

HCN4 shRNA (m) Lentiviral Particles

sc-42474-VmGene SilencingPuromycin0
(0)

HCN4 siRNA (r)

sc-270294rGene SilencingN/A0
(0)

HCN4 shRNA Plasmid (r)

sc-270294-SHrGene SilencingPuromycin0
(0)

HCN4 shRNA (r) Lentiviral Particles

sc-270294-VrGene SilencingPuromycin0
(0)

HCN CRISPR Knockout (KO) and HDR Plasmids

Empty Table HeaderProduct NameCATALOG #APPLICATIONSSpeciesCitationsRATING

HCN1 CRISPR/Cas9 KO Plasmid (h)

sc-404539Gene Knockouth0
(0)

HCN1 HDR Plasmid (h)

sc-404539-HDRHomology Directed Repairh0
(0)

HCN1 CRISPR/Cas9 KO Plasmid (m)

sc-420812Gene Knockoutm0
(0)

HCN1 HDR Plasmid (m)

sc-420812-HDRHomology Directed Repairm0
(0)

HCN2 CRISPR/Cas9 KO Plasmid (h)

sc-405074Gene Knockouth0
(0)

HCN2 CRISPR/Cas9 KO Plasmid (m)

sc-420813Gene Knockoutm0
(0)

HCN3 CRISPR/Cas9 KO Plasmid (m)

sc-420814Gene Knockoutm0
(0)

HCN3 HDR Plasmid (m)

sc-420814-HDRHomology Directed Repairm0
(0)

HCN4 CRISPR/Cas9 KO Plasmid (h)

sc-402293Gene Knockouth0
(0)

HCN4 HDR Plasmid (h)

sc-402293-HDRHomology Directed Repairh0
(0)

HCN CRISPR Double Nickase Plasmids

Empty Table HeaderProduct NameCATALOG #APPLICATIONSSpeciesCitationsRATING

HCN2 Double Nickase Plasmid (h)

sc-405074-NICGene Knockouth0
(0)

HCN2 Double Nickase Plasmid (h2)

sc-405074-NIC-2Gene Knockouth0
(0)

HCN3 Double Nickase Plasmid (h)

sc-407361-NICGene Knockouth0
(0)

HCN3 Double Nickase Plasmid (h2)

sc-407361-NIC-2Gene Knockouth0
(0)

HCN CRISPR Activation Plasmids and Lentiviral Particles

Empty Table HeaderProduct NameCATALOG #APPLICATIONSSpeciesCitationsRATING

HCN1 CRISPR Activation Plasmid (h)

sc-404539-ACTGene Activationh0
(0)

HCN2 CRISPR Activation Plasmid (h)

sc-405074-ACTGene Activationh0
(0)

HCN4 CRISPR Activation Plasmid (h)

sc-402293-ACTGene Activationh0
(0)

HCN4 CRISPR Activation Plasmid (h2)

sc-402293-ACT-2Gene Activationh0
(0)