Ran BP-M (K-12) Antibody: sc-46253

Ran BP-M Background Information
The small Ras-related protein Ran, also designated TC4, is a nuclear localized GTPase implicated in a diverse array of cellular processes including DNA replication, entry into and exit from mitosis, and the transport of RNA and proteins through the nuclear pore complex. Like Ras, active Ran GTP and inactive Ran GDP levels are tightly regulated by guanine nucleotide exchange factors (GEFs) and GTPase activating proteins (GAPs). Ran BP-M, also designated Ran-binding protein 9, is involved the nucleation of microtubule networks and may also act as an adapter protein in the coupling of membrane receptors to intracellular signaling pathways. It has been implicated in the activation of androgen and glucocorticoid receptor. Ran BP-M contains phosphorylated Serine residues. It can localize to both the nucleus and the cytoplasm, and a phosphorylated form can be associated with the plasma membrane. Ran BP-M is ubiquitously expressed, with highest expression levels in heart, testis, muscle and placenta. The enzymatic activity of the Ran BP-M protein is associated with breast cancer progression and fragile-X mental retardation.