epitope mapping near the C-terminus of NDR1 of human origin
recommended for detection of NDR1 of mouse, rat and human origin by WB, IF and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
NDR1 Background Information The nuclear Dbf2-related kinases (NDR1 and NDR2) participate in the regulation of cell division and morphology and may be implicated in tumor progression. NDR1 and NDR2 share 86% amino acid identity, but differ in their expression pattern. NDR1 localizes to the nucleus, while NDR2 exhibits punctate cytoplasmic distribution. Also, NDR1 expression appears highest in spleen, lung and thymus, whereas NDR2 shows highest expression in the gastrointestinal tract. However, both NDR1 and NDR2 are regulated by phosphorylation and by the Ca2+-binding protein S-100B. NDR1 and NDR2 may also play a role in the HIV-1 life cycle. Both proteins are cleaved by the HIV-1 protease (PR), which inhibits their enzymatic activity and alters the subcellular localization of NDR2. The genes encoding human NDR1 and NDR2 map to chromosomes 6p21 and 12p11.23, respectively.
