epitope mapping near the C-terminus of IMPDH of human origin
recommended for detection of IMPDH and IMPDH II of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
IMPDH Background Information A member of the GMPR family, inosine-5'-monophosphate dehydrogenase 1 (IMPDH1) functions in the regulation of cell growth by catalyzing the rate-limiting step in the de novo synthesis of guanine nucleotides. IMPDH1 is a ubiquitously expressed homotetramer that plays an important role in cyclic nucleoside metabolism within photoreceptors. Expression of IMPDH1 is the main type found in normal leukocytes, while IMPDH2 predominates in tumors. Mutations in IMPDH1 are associated with the autosomal dominant retinitis pigmentosa type 10 (RP10), as well as the development of malignant tumors. Analysis of mutant IMPDH1 suggests that protein misfolding and aggregation leads to the severe phenotype rather than reduced IMPDH1 activity. Therefore, IMPDH1 may be a potential therapeutic target based upon a strategy combining simultaneous suppression of IMPDH1 transcripts with supplementation of GTP within retinal tissues.
IMPDH (A-18)
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IMPDH (A-18): sc-46146. Western blot analysis of IMPDH expression in non-transfected: sc-117752 (A) and human IMPDH transfected: sc-113577 (B) 293T whole cell lysates.
