epitope mapping near the C-terminus of Sall3 of human origin
recommended for detection of Sall3 and, to a lesser extent, Sall1 and Sall4 of mouse, rat and human origin by WB, IF and ELISA; also reactive with additional species, including equine, canine, porcine and avian
blocking peptide, sc-46040 P
TransCruz reagent for Gel Supershift and ChIP applications, sc-46040 X, 200 µg/0.1 ml
Sall3 Background Information Sall3 (Sall3, sal-like 3) and SALL4 (Sall4, sal-like 4) are mammalian homologs of the Drosophila region-specific homeotic gene spalt (sal), which encodes a zinc finger-containing transcription regulator. Drosophila spalt (sal) is an essential genetic component required for the specification of posterior head and anterior tail as opposed to trunk. Sall3 is expressed at 24 weeks of gestation in several regions of the human fetal brain including neurons of the hippocampus formation and of mediodorsal and ventrolateral thalamic nuclei, Purkinje cells of the cerebellum, and a subset of neurons in the brainstem. Sall4 expression in early mouse embryos is gradually confined to the head region and the primitive streak, followed by prominent expression in the developing midbrain, branchial arches, limbs, and genital papilla.
