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- mouse monoclonal IgG2a; 100 µg/ml
- raised against GM-CSFRα transfected cells of human origin
- recommended for detection of 80 kDa GM-CSF receptor α chain of human origin by IP, IF and FCM
- neutralizes GM-CSF receptor biological activity
- also provided azide-free for neutralization of human native GM-CSFRα, sc-458 L, 100 µg/0.1 ml
- fluorescein (sc-458 FITC) and phycoerythrin (sc-458 PE) conjugates for FCM, 100 tests
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GM-CSFRα Background Information
The human IL-3, IL-5 and GM-CSF receptors are each composed of both unique a subunits and a common ∫ subunit. The a subunits are low affinity ligand binding proteins while the ∫ subunits do not themselves bind ligand, but are required for high affinity binding by the a subunits (1–5). In contrast, the mouse IL-3 receptor has two distinct ∫ subunits, one that functions only in IL-3 mediated cell signaling and a second that is shared with IL-5 and GM-CSF (6). The murine ∫-subunits are 91% homologous at the amino acid level but only 56% homologous to the human ∫ subunit (6). Although neither the murine nor the human ∫ subunit contains tyrosine kinase domains, both activate tyrosine phosphorylation mediated signaling pathways (7,8).
| GM-CSFRα (S-20) Product Citations |
See how others have used GM-CSFRα (S-20): sc-458 antibody and or GM-CSFRα (S-20) antibody conjugates.
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GM-CSFRα (S-20)
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GM-CSFRα (S-20) FITC: sc-458 FITC. FCM analysis of human peripheral blood leukocytes. Black line histogram represents the isotype control, normal mouse IgG 2a: sc-2856. |
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