santa cruz biotechnology, inc.
SCBT Logo

Welcome!        Items in Cart     Quick Order
home » Transcription Regulators » c-Fos Antibody / c-Fos Antibodies » c-Fos (6-2H-2F): sc-447

c-Fos (6-2H-2F) Antibody: sc-447

  |  Datasheet
  • mouse monoclonal IgG1; 200 µg/ml
  • epitope mapping between amino acids 139-211 (leucine zipper) of c-Fos of human origin
  • recommended for detection of c-Fos, Fos B, Fra-1 and Fra-2 of mouse, rat and human origin by WB and IP
  • agarose conjugate for IP studies, sc-447 AC, 500 µg/0.25 ml agarose
  • TransCruz reagent for Gel Supershift and ChIP applications, sc-447 X, 200 µg/0.1 ml
 
Additional c-Fos Antibodies ...
 
Ordering InformationProduct Citations
Recommended Support Products:
(click button of application of choice)
WB   IP   Gel Shift   ChIP   siRNA  
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human FOS 2353 14q24.3 NM_005252 P01100
 164810
Mouse Fos 14281 12 D2 P01101
 N/A
 
Set Currency

 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
c-Fos (6-2H-2F) sc-447 200 µg/ml $279
c-Fos (6-2H-2F) AC sc-447 AC 500µg/ml, 25%ag $366
c-Fos (6-2H-2F) X sc-447 X 200 µg/0.1 ml $279
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
c-Fos siRNA (h) sc-29221 10 µM $258
c-Fos siRNA (m) sc-29222 10 µM $258
c-Fos siRNA (h2) sc-44200 10 µM $258
c-Fos (h)-PR sc-29221-PR 10 µM $23
c-Fos (m)-PR sc-29222-PR 10 µM $23
c-Fos (h2)-PR sc-44200-PR 10 µM $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
c-Fos shRNA Plasmid (h) sc-29221-SH 20 µg $520
c-Fos shRNA Plasmid (m) sc-29222-SH 20 µg $520
c-Fos shRNA Plasmid (h2) sc-44200-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
c-Fos shRNA (h) Lentiviral Particles sc-29221-V 200 µl $625
c-Fos shRNA (m) Lentiviral Particles sc-29222-V 200 µl $625
c-Fos shRNA (h2) Lentiviral Particles sc-44200-V 200 µl $625
 WB Positive Control Cell Lysates (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
A-431 Whole Cell Lysate sc-2201 500 µg/200 µl $104
A-431 nuclear extract sc-2122 1000 µg $143
Jurkat Whole Cell Lysate sc-2204 500 µg/200 µl $104
Jurkat + PMA nuclear extract sc-2133 1000 µg $143
A549 Cell Lysate sc-2413 500 µg/200 µl $104
Y79 nuclear extract sc-2126 1000 µg $143
PC-3 Cell Lysate sc-2220 500 µg/200 µl $104
HeLa Whole Cell Lysate sc-2200 500 µg/200 µl $104

c-Fos Background Information
The c-Fos oncogene was initially detected in two independent murine osteosarcoma virus isolates and an avian nephroblastoma virus. The cellular homolog, c-Fos, encodes a nuclear phospho-protein that is rapidly and transiently induced by a variety of agents and functions as a transcriptional regulator for several genes. In contrast to c-Jun proteins, which form homo- and heterodimers which bind to specific DNA response elements, c-Fos proteins are only active as heterodimers with members of the Jun gene family. Functional homologs of c-Fos include the Fra-1, Fra-2 and Fos B genes. In addition, selected ATF/CREB family members can form leucine zipper dimers with Fos and Jun. Different dimers exhibit differential specificity and affinity for AP-1 and CRE sites.

c-Fos (6-2H-2F) Product Citations
See how others have used c-Fos (6-2H-2F): sc-447 antibody and or c-Fos (6-2H-2F) antibody conjugates.


23 total citations
Loading citations.
 
c-Fos (6-2H-2F)
Click on image to enlarge
sc-447
c-Fos (6-2H-2F): sc-447. Western blot analysis of Fos gene family protein expression in A-431 (A) and Y79 (B) nuclear extracts.
sc-447
ChiP analysis of transcription factor binding to the CD28 responsive positive regulatory region IV (PRRIV) in resting (A,B) and CD3+CD28-stimulated human primary T cells. 10% (A,C) and 1% (B,D) of input DNAs were amplified. Antibodies used included c-Jun (D): sc-44; c-Fos (6-2H-2F): sc-447 and Ets-1/Ets-2 (C-275): sc-112. Data kindly provided by J. Imbert and reproduced with permission from Yeh, J.H., et al, Mol. Cell. Biol., 2001, 21:4515-4527.
Download
Datasheets
Get Adobe Acrobat Reader