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PLC γ1 Antibody (530): sc-426

 |  Datasheet

(Based on data analysis)

  • PLC γ1 Antibody (530) is a rabbit polyclonal IgG provided at 200 µg/ml
  • epitope corresponding to amino acids 530-850 of PLC γ1 of rat origin
  • recommended for detection of PLC γ1 p145 of mouse, rat, human and hamster origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
  • See 34 citations for PLC γ1 Antibody (530)
 
Full-length PLC γ1 protein sequence with immunogen highlighted:
MAGVGTPCANGCGPSAPSEAEVLHLCRSLEVGTVMTLFYSKKSQRPERKTFQVKLETRQITWSRGADKIEGSIDIREIKEIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKTLSLQATSEDEVNMWIKGLTWLMEDTLQAATPLQIERWLRKQFYSVDRNREDRISAKDLKNMLSQVNYRVPNMRFLRERLTDFEQRSGDITYGQFAQLYRSLMYSAQKTMDLPFLETNTLRTGERPELCQVSLSEFQQFLLEYQGELWAVDRLQVQEFMLSFLRDPLREIEEPYFFLDELVTFLFSKENSVWNSQLDAVCPETMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMGCRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIAQQRNMAQHFRKVLGDTLLTKPVDIAADGLPSPNQLKRKILIKHKKLAEGSAYEEVPTSVMYSENDISNSIKNGILYLEDPVNHEWYPHYFVLTSSKIYYSEETSSDQGNEDEEEPKEASGSTELHSSEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFWRNGKVQHCRIHSRQDAGTPKFFLTDNLVFDSLYDLITHYQQVPLRCNEFEMRLSEPVPQTNAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRNEPNSYAISFRAEGKIKHCRVQQEGQTVMLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEEALEKIGTAEPDYGALYEGRNPGFYVEANPMPTFKCAVKALFDYKAQREDELTFTKSAIIQNVEKQDGGWWRGDYGGKKQLWFPSNYVEEMINPAILEPEREHLDENSPLGDLLRGVLDVPACQIAIRPEGKNNRLFVFSISMPSVAQWSLDVAADSQEELQDWVKKIREVAQTADARLTEGKMMERRKKIALELSELVVYCRPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGKKFLQYNRLQLSRIYPKGQRLDSSNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFMAGGHCGYVLQPSTMRDEAFDPFDKSSLRGLEPCVICIEVLGARHLPKNGRGIVCPFVEIEVAGAEYDSTKQKTEFVVDNGLNPVWPAKPFHFQISNPEFAFLRFVVYEEDMFSDQNFLAQATFPVKGLKTGYRAVPLKNNYSEDLELASLLIKIDIFPAKENGDLSPFSGTSLRERASDASSQLFHVRAREGSFEARYQQPFEDFRISQEHLADHFDSRERRAPRRTRVNGDNRL

See additional PLC Antibodies including PLC, PLC beta 1, PLC delta 1, PLC epsilon, PLC eta 1, PLC gamma 1, PLC zeta, PLC-L, PLC-XD1, PLC-XD2, PLC-XD3, PLC beta 2, PLC epsilon 2, PLC eta 2, PLC gamma 2, PLC beta 3, PLC delta 3, PLC beta 4 and PLC delta 4.

Also see chemical PLC Inhibitors, chemical PLC Activators or chemical PLC Substrates for functional analysis of cellular responses to PLC.


Ordering InformationProduct CitationsGene Info
Recommended Support Products:
(click button of application of choice)
WB   IP   IF   siRNA  
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 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
PLC γ1 Antibody (530) sc-426 200 µg/ml $279
 CRISPR/Cas9 KO and HDR Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
PLC γ1 CRISPR/Cas9 KO Plasmid (h) sc-400472 20 µg $345
PLC γ1 HDR Plasmid (h) sc-400472-HDR 20 µg $385
PLC γ1 CRISPR/Cas9 KO Plasmid (m) sc-422299 20 µg $345
PLC γ1 HDR Plasmid (m) sc-422299-HDR 20 µg $385
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
PLC γ1 siRNA (h) sc-29452 10 µM $258
PLC γ1 siRNA (m) sc-36265 10 µM $258
PLC γ1 (h)-PR sc-29452-PR 10 µM, 20 µl $23
PLC γ1 (m)-PR sc-36265-PR 10 µM, 20 µl $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
PLC γ1 shRNA Plasmid (h) sc-29452-SH 20 µg $520
PLC γ1 shRNA Plasmid (m) sc-36265-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
PLC γ1 shRNA (h) Lentiviral Particles sc-29452-V 200 µl $625
PLC γ1 shRNA (m) Lentiviral Particles sc-36265-V 200 µl $625
 WB Positive Control Cell Lysates (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
A-431 Whole Cell Lysate sc-2201 500 µg/200 µl $104
CHO-K1 Cell Lysate sc-3809 500 µg/200 µl $104
NIH/3T3 Whole Cell Lysate sc-2210 500 µg/200 µl $104
KNRK Whole Cell Lysate sc-2214 500 µg/200 µl $104
mouse lung extract sc-2390 500 µg/200 µl $104
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human PLCG1 5335 20q12 NM_002660, NM_182811 P19174
172420
Mouse Plcg1 18803 2 H2 Q62077
N/A
 


Phosphoinositide-specific phospholipase C (PLC) plays a crucial role in the initiation of receptor mediated signal transduction through the generation of the two second messengers, inositol 1,4,5-triphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. There are many mammalian PLC isozymes, including PLC ∫1, PLC ∫2, PLC ∫3, PLC ∫4, PLC ©1, PLC ©2, PLC ∂1, PLC ∂2 and PLC é. PLC ©1 is widely distributed in bronchiolar epithelium, type I and II pneumocytes and fibroblasts of the interstitial tissue. Actin-regulatory protein Villin is tyrosine phosphorylated and associates with PLC ©1 in the brush border of intestinal epithelial cells. Villin regulates PLC ©1 activity by modifying its own ability to bind phosphatidylinositol 4,5-biphosphate. PLC ©1 binds Integrin å1/∫1 and modulates Integrin å1/∫-specific adhesion. PLC ©1 and Ca2+ play a direct role in VEGF-regulated endothelial growth, however this signaling pathway is not linked to FGF-mediated effects in primary endothelial cells. PLC ©1 is rapidly activated in response to growth factor stimulation and plays an important role in regulating cell proliferation and differentiation. It may also have a protective function during cellular response to oxidative stress.

PLC γ1 Antibody (530) Product Citations
See how others have used PLC γ1 Antibody (530) and or PLC γ1 Antibody (530) conjugates.


34 total citations
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PLC γ1 Antibody (530) Data
Click on image to enlarge
PLC γ1 (530): sc-426. Western blot analysis of PLC γ1 expression in CHO-K1 (A), A-431 (B), NIH/3T3 (C) and KNRK (D) whole cell lysates.
PLC γ1 (530): sc-426. Immunofluorescence staining of methanol-fixed A-431 cells showing membrane and cytoplasmic staining.
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