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Stat1α p91 (C-111) Antibody: sc-417 |
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- mouse monoclonal IgG1; 200 µg/ml
- epitope mapping between amino acids 613-739 of Stat1α p91 of human origin
- recommended for detection of Stat1α p91 of mouse and human origin by WB, IP and IF
- TransCruz reagent for Gel Supershift and ChIP applications, sc-417 X, 200 µg/0.1 ml
- agarose conjugate for IP studies, sc-417 AC, 500 µg/0.25 ml agarose
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Stat1α p91 Background Information
Membrane receptor signaling by various ligands, including interferons and growth hormones such as EGF, induces activation of JAK kinases which then leads to tyrosine phosphorylation of the various Stat transcription factors. Stat1 and Stat2 are induced by IFN-å and form a heterodimer which is part of the ISGF3 transcription factor complex. Although early reports indicate Stat3 activation by EGF and IL-6, it has been shown that Stat3∫ appears to be activated by both while Stat3å is activated by EGF, but not by IL-6. Highest expression of Stat4 is seen in testis and Myeloid cells. IL-12 has been identified as an activator of Stat4. Stat5 has been shown to be activated by Prolactin and by IL-3. Stat6 is involved in IL-4 activated signaling pathways.
| Stat1α p91 (C-111) Product Citations |
See how others have used Stat1α p91 (C-111): sc-417 antibody and or Stat1α p91 (C-111) antibody conjugates.
43 total citations Loading citations.
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Stat1α p91 (C-111)
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Western blot analysis of Stat1 phosphorylation in untreated (A,C) and IFN-γ-treated (B,D) SK-MEL-28 cell cultures. Lanes A,B and C,D probed, respectively, with Stat1α p91 (C-111): sc-417 (A,B) or with p-Stat1 (Tyr 701): sc-7988 (C,D). Western blot analysis of Stat1α p91 expression in NIH/3T3 nuclear extracts (A,B). Antibodies tested include Stat1α p91 (M-23): sc-591 (A) and Stat1α p91 (C-111): sc-417 (B). Western blot detection of Stat1 phosphorylation using untreated (A,C) and IFN-γ-treated (B,D) HeLa cells. Antibodies tested include p-Stat1 (Tyr 701): sc-7988-R (A,B) and Stat1α p91 (C-111): sc-417 (C,D). Western blot analysis of Stat1 activation in untreated (A,C) and γ-interferon-induced (B,D) HeLa cells. Antibodies tested include a phospho-specific Stat1 monoclonal, p-Stat1 (A-2): sc-8394 (A,B) and a control antibody, Stat1a p91 (C-111): sc-417 (C,D). Stat1α p91 (C-111): sc-417. Western blot analysis of Stat1 p84/p91 expression in non-transfected: sc-117752 (A) and mouse Stat1 p84/p91 transfected: sc-123815 (B) 293T whole cell lysates. Stat1α p91 (C-111): sc-417. Western blot analysis of Stat1α p91 If expression in HeLa whole cell lysate.
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