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home » Cell Cycle Proteins » p21 Antibody / p21 Antibodies » p21 (C-19): sc-397

p21 (C-19) Antibody: sc-397

  |  Datasheet
  • rabbit polyclonal IgG, 200 µg/ml; also available as goat IgG, 200 µg/ml, sc-397-G
  • epitope mapping at the C-terminus of p21 of human origin
  • recommended for detection of p21 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and feline
  • blocking peptide, sc-397 P
  • agarose conjugate for IP studies, sc-397 AC, 500 µg/0.25 ml agarose
  • HRP conjugate, sc-397 HRP, 200 µg/ml
  • fluorescein (sc-397 FITC) and rhodamine (sc-397 TRITC) conjugates for immunofluorescence, 200 µg/ml
  • Alexa Fluor® 405 (sc-397 AF405), Alexa Fluor® 488 (sc-397 AF488) and Alexa Fluor® 647 (sc-397 AF647) conjugates for immunofluorescence; 100 µg/2 ml
 
Additional p21 Antibodies ...
 
Ordering InformationProduct Citations
Recommended Support Products:
(click button of application of choice)
WB   IP   IF   IHC(P)   siRNA  
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human CDKN1A 1026 6p21.31 NM_000389, NM_078467 P38936
 116899
Mouse Cdkn1a 12575 17 A3.3 P39689
 N/A
 
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 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
p21 (C-19) sc-397 200 µg/ml $279
p21 (C-19) AC sc-397 AC 500µg/ml, 25%ag $366
p21 (C-19) Alexa Fluor® 405 sc-397 AF405 100 µg/2 ml $314
p21 (C-19) Alexa Fluor® 488 sc-397 AF488 100 µg/2 ml $314
p21 (C-19) Alexa Fluor® 647 sc-397 AF647 100 µg/2 ml $314
p21 (C-19) FITC sc-397 FITC 200 µg/ml $282
p21 (C-19) HRP sc-397 HRP 200 µg/ml $279
p21 (C-19) P sc-397 P
(peptide)
 100 µg/0.5 ml $61
p21 (C-19) TRITC sc-397 TRITC 200 µg/ml $282
p21 (C-19)-G sc-397-G 200 µg/ml $279
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
p21 siRNA (h) sc-29427 10 µM $258
p21 siRNA (m) sc-29428 10 µM $258
p21 siRNA (r) sc-108036 10 µM $258
p21 siRNA (m2) sc-44271 10 µM $258
p21 (h)-PR sc-29427-PR 10 µM $23
p21 (m)-PR sc-29428-PR 10 µM $23
p21 (r)-PR sc-108036-PR 10 µM $23
p21 (m2)-PR sc-44271-PR 10 µM $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
p21 shRNA Plasmid (h) sc-29427-SH 20 µg $520
p21 shRNA Plasmid (m) sc-29428-SH 20 µg $520
p21 shRNA Plasmid (r) sc-108036-SH 20 µg $520
p21 shRNA Plasmid (m2) sc-44271-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
p21 shRNA (h) Lentiviral Particles sc-29427-V 200 µl $625
p21 shRNA (m) Lentiviral Particles sc-29428-V 200 µl $625
p21 shRNA (r) Lentiviral Particles sc-108036-V 200 µl $625
p21 shRNA (m2) Lentiviral Particles sc-44271-V 200 µl $625
 WB Positive Control Cell Lysates (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
KNRK nuclear extract sc-2141 1000 µg $143
C32 nuclear extract sc-2136 1000 µg $143
C32 + PMA nuclear extract sc-2137 1000 µg $143
NIH/3T3 nuclear extract sc-2138 1000 µg $143
C32 Whole Cell Lysate sc-2205 500 µg/200 µl $104

p21 Background Information
It is now well established that cyclins play a positive role in promoting cell cycle transitions via their ability to associate with and activate their cognate cyclin-dependent kinases (Cdks). Cdk2 associates with cyclins A, D and E, and has been implicated in the control of the G1 to S phase transition in mammals. A novel Cdk-interacting protein, designated p21, Cip1 or WAF1, has been identified in cyclin A, cyclin D1, cyclin E and Cdk2 immunoprecipitates. p21 is a potent, tight-binding inhibitor of Cdks and can inhibit the phosphorylation of Rb by cyclin A-Cdk 2, cyclin E-Cdk2, cyclin D1-Cdk4 and cyclin D2-Cdk4 complexes. Expression of p21 is inducible by wildtype, but not mutant, p53. The mouse homolog of p21 is designated CAP20.

p21 (C-19) Product Citations
See how others have used p21 (C-19): sc-397 antibody and or p21 (C-19) antibody conjugates.


680 total citations
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Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
 
p21 (C-19)
Click on image to enlarge
sc-397
Western blot analysis of p21 expression in untreated (A,C,E) and phorbol ester-induced (B,D,F) C32 nuclear extracts. Antibodies tested include p21 (187): sc-817 (A,B), p21 (C-19)-G: sc-397-G (C,D) and p21 (C-19): sc-397 (E,F).
sc-397
p21 (C-19)-G: sc-397-G. Western blot analysis of p21 expression in HeLa nuclear extract.
sc-397
p21 (C-19): sc-397. Western blot analysis of p21 expression in non-transfected 293T: sc-117752 (A), mouse p21 transfected 293T: sc-122305 (B) and C32 (C) whole cell lysates.
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