Molecular structure of Robotnikinin, CAS Number: 1132653-79-2
Robotnikinin (CAS 1132653-79-2)
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Alternate Names:
N-[(4-Chlorophenyl)methyl]-2-[(2R,6S,8E)-5,12-dioxo-2- phenyl-1-oxa-4-azacyclododec-8-en-6-yl]acetamide
Application:
Robotnikinin is A Sonic hedgehog (Shh) signaling modulator
CAS Number:
1132653-79-2
Molecular Weight:
454.95
Molecular Formula:
C25H27ClN2O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Robotnikinin is a small molecule inhibitor that targets the protein kinase PIM1. It is a potent and selective inhibitor of PIM1, with an IC50 value in the low nanomolar range. Robotnikinin effectively inhibit the activity of PIM1, which plays a key role in regulating cell proliferation, survival, and apoptosis. By targeting PIM1, Robotnikinin has the potential to modulate various cellular processes and signaling pathways. This makes Robotnikinin a promising for studying the function of PIM1 and for developing new strategies with dysregulated PIM1 activity.
Robotnikinin (CAS 1132653-79-2) References
- A small molecule that binds Hedgehog and blocks its signaling in human cells. | Stanton, BZ., et al. 2009. Nat Chem Biol. 5: 154-6. PMID: 19151731
- Syntheses of aminoalcohol-derived macrocycles leading to a small-molecule binder to and inhibitor of Sonic Hedgehog. | Peng, LF., et al. 2009. Bioorg Med Chem Lett. 19: 6319-25. PMID: 19819139
- Small-molecule modulators of the Sonic Hedgehog signaling pathway. | Stanton, BZ. and Peng, LF. 2010. Mol Biosyst. 6: 44-54. PMID: 20024066
- Expanding the range of 'druggable' targets with natural product-based libraries: an academic perspective. | Bauer, RA., et al. 2010. Curr Opin Chem Biol. 14: 308-14. PMID: 20202892
- Discovery and evaluation of potential sonic hedgehog signaling pathway inhibitors using pharmacophore modeling and molecular dynamics simulations. | Hwang, S., et al. 2011. J Bioinform Comput Biol. 9 Suppl 1: 15-35. PMID: 22144251
- Molecular pathways: the role of primary cilia in cancer progression and therapeutics with a focus on Hedgehog signaling. | Hassounah, NB., et al. 2012. Clin Cancer Res. 18: 2429-35. PMID: 22415315
- Macrocyclic Hedgehog Pathway Inhibitors: Optimization of Cellular Activity and Mode of Action Studies. | Dockendorff, C., et al. 2012. ACS Med Chem Lett. 3: 808-813. PMID: 23074541
- Diversity-oriented synthesis as a tool for chemical genetics. | Lenci, E., et al. 2014. Molecules. 19: 16506-28. PMID: 25317579
- Molecular pathways: novel approaches for improved therapeutic targeting of Hedgehog signaling in cancer stem cells. | Justilien, V. and Fields, AP. 2015. Clin Cancer Res. 21: 505-13. PMID: 25646180
- The Binding Mode of the Sonic Hedgehog Inhibitor Robotnikinin, a Combined Docking and QM/MM MD Study. | Hitzenberger, M., et al. 2017. Front Chem. 5: 76. PMID: 29109946
- Chemical probes and drug leads from advances in synthetic planning and methodology. | Gerry, CJ. and Schreiber, SL. 2018. Nat Rev Drug Discov. 17: 333-352. PMID: 29651105
- Discovery of Small Molecule Inhibitors Targeting the Sonic Hedgehog. | Yun, T., et al. 2020. Front Chem. 8: 498. PMID: 32612978
- Berberine inhibits colorectal tumor growth by suppressing SHH secretion. | Shen, ZQ., et al. 2021. Acta Pharmacol Sin. 42: 1190-1194. PMID: 32958873
Inhibitor of:
DCHS2, DISP1, Gas1, hedgehog, Hhip, LMBR1, patched 2, Scratch1, Shh, Smo, STK36, TMEM218, and VAX1.Activator of:
AP-2α, cubitus interruptus, Draxin, and HIP3.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Robotnikinin, 1 mg | sc-396554 | 1 mg | $650.00 |