Molecular structure of Illudin S, CAS Number: 1149-99-1
Illudin S (CAS 1149-99-1)
See product citations (8)
Alternate Names:
Lampterol
Application:
Illudin S is a potent antitumor sesquiterpene
CAS Number:
1149-99-1
Purity:
≥95%
Molecular Weight:
264.32
Molecular Formula:
C15H20O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Illudin S is potent fungal sesquiterpene that, through their unique DNA alkylating actions, have anticancer potential. Illudin S is metabolically activated to reactive intermediates that bind DNA. The DNA damage appears to differ from that of other reactive metabolites. Importantly, illudin S exhibits in vitro and in vivo potency against multi-drug resistant tumours.
Illudin S (CAS 1149-99-1) References
- Metabolism of antitumor hydroxymethylacylfulvene by rat liver cytosol. | McMorris, TC., et al. 1999. Drug Metab Dispos. 27: 983-5. PMID: 10460795
- Anti-tumour compounds illudin S and Irofulven induce DNA lesions ignored by global repair and exclusively processed by transcription- and replication-coupled repair pathways. | Jaspers, NG., et al. 2002. DNA Repair (Amst). 1: 1027-38. PMID: 12531012
- Profiling patterns of glutathione reductase inhibition by the natural product illudin S and its acylfulvene analogues. | Liu, X. and Sturla, SJ. 2009. Mol Biosyst. 5: 1013-24. PMID: 19668867
- [Determination of illudin S in Omphalotus guepiniformis and foods that caused food poisoning by liquid chromatography with tandem mass spectrometry]. | Kasahara, Y. and Itou, T. 2009. Shokuhin Eiseigaku Zasshi. 50: 167-72. PMID: 19745584
- On the mechanism of toxicity of illudins: the role of glutathione. | McMorris, TC., et al. 1990. Chem Res Toxicol. 3: 574-9. PMID: 2103329
- Metabolism of illudin S, a toxic principle of Lampteromyces japonicus, by rat liver. I. Isolation and identification of cyclopropane ring-cleavage metabolites. | Tanaka, K., et al. 1990. Xenobiotica. 20: 671-81. PMID: 2238702
- Sulfotransferase-independent genotoxicity of illudin S and its acylfulvene derivatives in bacterial and mammalian cells. | Glatt, H., et al. 2014. Arch Toxicol. 88: 161-9. PMID: 23881331
- Mutagenicity of ptaquiloside, the carcinogen in bracken, and its related illudane-type sesquiterpenes. I. Mutagenicity in Salmonella typhimurium. | Nagao, T., et al. 1989. Mutat Res. 215: 173-8. PMID: 2689878
- Repair of UV-Induced DNA Damage Independent of Nucleotide Excision Repair Is Masked by MUTYH. | Mazouzi, A., et al. 2017. Mol Cell. 68: 797-807.e7. PMID: 29149600
- Application of High-speed Countercurrent Chromatography for the Purification of High-purity Illudin S from Omphalotus japonicus. | Uto, Y., et al. 2019. Anal Sci. 35: 789-792. PMID: 30930353
- The mutational impact of Illudin S on human cells. | Casimir, L., et al. 2023. DNA Repair (Amst). 122: 103433. PMID: 36566616
- Characterization of illudin S sensitivity in DNA repair-deficient Chinese hamster cells. Unusually high sensitivity of ERCC2 and ERCC3 DNA helicase-deficient mutants in comparison to other chemotherapeutic agents. | Kelner, MJ., et al. 1994. Biochem Pharmacol. 48: 403-9. PMID: 8053936
- Histopathological effects of illudin S, a toxic substance of poisonous mushroom, in rat. | Tanaka, K., et al. 1996. Hum Exp Toxicol. 15: 289-93. PMID: 8845217
- Michael-type addition of illudin S, a toxic substance from Lampteromyces japonicus, with cysteine and cysteine-containing peptides in vitro. | Tanaka, K., et al. 1996. Chem Pharm Bull (Tokyo). 44: 273-9. PMID: 8998835
- Characterization of cellular accumulation and toxicity of illudin S in sensitive and nonsensitive tumor cells. | Kelner, MJ., et al. 1997. Cancer Chemother Pharmacol. 40: 65-71. PMID: 9137532
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Illudin S, 1 mg | sc-391575 | 1 mg | $340.00 | |||
Illudin S, 5 mg | sc-391575A | 5 mg | $1199.00 |