MFSD7 Antibody (B-7): sc-390083

MFSD7 Antibody (B-7) is a mouse monoclonal IgG2b kappa light chain antibody that detects MFSD7 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). MFSD7 (B-7) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. MFSD7, also known as major facilitator superfamily domain-containing protein 7, is a 560 amino acid multi-pass membrane protein that plays a crucial role in the transport of small solutes across cellular membranes, utilizing chemiosmotic ion gradients. This function is vital for maintaining cellular homeostasis and facilitating nutrient uptake, particularly important in tissues with high metabolic demands. MFSD7 exists in three alternatively spliced isoforms, highlighting potential versatility in various physiological contexts. The gene encoding MFSD7 is located on human chromosome 4, a region associated with several genetic disorders, including Huntington′s disease and polycystic kidney disease, underscoring MFSD7′s importance in both health and disease. MFSD7 is related to MFSD2, a protein implicated in placenta morphogenesis and adaptive thermogenesis, suggesting potential roles in developmental processes and metabolic regulation.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

MFSD7 Antibody (B-7) References:

1. Generation and annotation of the DNA sequences of human chromosomes 2 and 4.  |  Hillier, LW., et al. 2005. Nature. 434: 724-31. PMID: 15815621
2. Growth hormone analysis and treatment in Ellis-van Creveld syndrome.  |  Versteegh, FG., et al. 2007. Am J Med Genet A. 143A: 2113-21. PMID: 17702014
3. Neuroprotective effects of synaptic modulation in Huntington's disease R6/2 mice.  |  Stack, EC., et al. 2007. J Neurosci. 27: 12908-15. PMID: 18032664
4. Ring chromosome 21 and reproductive pattern: a familial case and review of the literature.  |  Bertini, V., et al. 2008. Fertil Steril. 90: 2004.e1-5. PMID: 18371955
5. Mfsd2a encodes a novel major facilitator superfamily domain-containing protein highly induced in brown adipose tissue during fasting and adaptive thermogenesis.  |  Angers, M., et al. 2008. Biochem J. 416: 347-55. PMID: 18694395
6. Bacterial multidrug transport through the lens of the major facilitator superfamily.  |  Fluman, N. and Bibi, E. 2009. Biochim Biophys Acta. 1794: 738-47. PMID: 19103310
7. The secondary multidrug/proton antiporter MdfA tolerates displacements of an essential negatively charged side chain.  |  Sigal, N., et al. 2009. J Biol Chem. 284: 6966-71. PMID: 19129186

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-MFSD7 Antibody (B-7) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-MFSD7 Antibody (B-7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

MFSD7 Antibody (B-7) Specifications

Alternate Product Name: MFSD7

Product Clone Name: B-7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 293-325

Epitope Target: MFSD7

Epitope Species: human

Product Reactivity/Detection: MFSD7 isoforms 1-4

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for MFSD7 Antibody (B-7): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin