KV1.5 Antibody (A-3): sc-377110

KV1.5 Antibody (A-3) is a mouse monoclonal IgG3 kappa light chain antibody that detects KV1.5 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). KV1.5 (A-3) antibody is available as the non-conjugated form. KV1.5 protein plays a crucial role in regulating electrical signaling in excitable cells, such as neurons and muscle cells, by forming part of voltage-gated potassium channels essential for repolarizing cell membranes after action potentials. These channels maintain proper frequency and timing of action potentials, necessary for effective cell-to-cell communication. KV1.5 protein, along with counterparts in the KV gene family, contributes to forming tetrameric channel complexes that exhibit distinct gating and permeation properties, allowing precise control of ion flow across plasma membranes. Understanding KV1.5 function and interactions with other proteins is important for elucidating mechanisms underlying various physiological processes and potential pathologies, including cardiac arrhythmias and neurological disorders.

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KV1.5 Antibody (A-3) References:

1. Subunit composition of Kv1 channels in human CNS.  |  Coleman, SK., et al. 1999. J Neurochem. 73: 849-58. PMID: 10428084
2. Subunit composition determines Kv1 potassium channel surface expression.  |  Manganas, LN. and Trimmer, JS. 2000. J Biol Chem. 275: 29685-93. PMID: 10896669
3. Kv1.5-Kv beta interactions: molecular determinants and pharmacological consequences.  |  González, T., et al. 2010. Mini Rev Med Chem. 10: 635-42. PMID: 20500153
4. The voltage-dependent K(+) channels Kv1.3 and Kv1.5 in human cancer.  |  Comes, N., et al. 2013. Front Physiol. 4: 283. PMID: 24133455
5. Kv1.5 Inhibitors for Treatment of Atrial Fibrillation: A Tradeoff between Selectivity and Non-selectivity.  |  Guo, X., et al. 2016. Curr Top Med Chem. 16: 1843-54. PMID: 26975505
6. Challenges Faced with Small Molecular Modulators of Potassium Current Channel Isoform Kv1.5.  |  Zhao, Z., et al. 2019. Biomolecules. 10: PMID: 31861703
7. Kv1.5 channels are regulated by PKC-mediated endocytic degradation.  |  Du, Y., et al. 2021. J Biol Chem. 296: 100514. PMID: 33676894
8. Kv1.5 channel mediates monosodium urate-induced activation of NLRP3 inflammasome in macrophages and arrhythmogenic effects of urate on cardiomyocytes.  |  Li, P., et al. 2022. Mol Biol Rep. 49: 5939-5952. PMID: 35368226
9. The brain Kv1.1 potassium channel: in vitro and in vivo studies on subunit assembly and posttranslational processing.  |  Deal, KK., et al. 1994. J Neurosci. 14: 1666-76. PMID: 8126562
10. Immunohistochemical localization of five members of the Kv1 channel subunits: contrasting subcellular locations and neuron-specific co-localizations in rat brain.  |  Veh, RW., et al. 1995. Eur J Neurosci. 7: 2189-205. PMID: 8563969
11. Beta subunits promote K+ channel surface expression through effects early in biosynthesis.  |  Shi, G., et al. 1996. Neuron. 16: 843-52. PMID: 8608002
12. Association and colocalization of the Kvbeta1 and Kvbeta2 beta-subunits with Kv1 alpha-subunits in mammalian brain K+ channel complexes.  |  Rhodes, KJ., et al. 1997. J Neurosci. 17: 8246-58. PMID: 9334400

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-KV1.5 Antibody (A-3) has 10 citations in a variety of scientific publications.

Primary antibodies like Anti-KV1.5 Antibody (A-3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

KV1.5 Antibody (A-3) Specifications

Alternate Product Name: KV1.5

Product Clone Name: A-3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₃ kappa light chain

Amino Acids: 5-39

Epitope Target: KV1.5

Epitope Species: human

Product Reactivity/Detection: KV1.5

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₃ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 10 citations in various scientific publications

Available Conjugates/Forms for KV1.5 Antibody (A-3): P: Blocking Peptide