C3G Antibody (F-5): sc-376992

C3G Antibody (F-5) is a mouse monoclonal IgG1 antibody that detects C3G in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). C3G plays a crucial role as a guanine nucleotide exchange factor (GEF) for Ras, a key regulator in various cellular processes, including cell growth, differentiation, and survival. C3G (F-5) antibody helps researchers study how C3G activates Ras by facilitating the exchange of GDP for GTP, which is vital for proper cellular signaling; dysregulation of this process can lead to oncogenic transformations and contribute to cancer progression. Located in the cytoplasm, C3G interacts with the Crk proto-oncogene product, linking it to pathways that modulate Ras activity. The C3G gene is situated on human chromosome 9q34.13, near the c-Abl gene, which is also implicated in cancer. Anti-C3G antibody (F-5) serves as an essential tool for researchers studying the intricate mechanisms of Ras signaling and its implications in tumor biology, providing insights into potential therapeutic targets for cancer treatment.

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C3G Antibody (F-5) References:

1. C3G (RapGEF1), a regulator of actin dynamics promotes survival and myogenic differentiation of mouse mesenchymal cells.  |  Sasi Kumar, K., et al. 2015. Biochim Biophys Acta. 1853: 2629-39. PMID: 26133694
2. C3G shows regulated nucleocytoplasmic exchange and represses histone modifications associated with euchromatin.  |  Shakyawar, DK., et al. 2017. Mol Biol Cell. 28: 984-995. PMID: 28148649
3. C3G, through its GEF activity, induces megakaryocytic differentiation and proplatelet formation.  |  Ortiz-Rivero, S., et al. 2018. Cell Commun Signal. 16: 101. PMID: 30567575
4. Neuroprotective effects of anthocyanins and its major component cyanidin-3-O-glucoside (C3G) in the central nervous system: An outlined review.  |  Zhang, J., et al. 2019. Eur J Pharmacol. 858: 172500. PMID: 31238064
5. C3G contributes to platelet activation and aggregation by regulating major signaling pathways.  |  Gutiérrez-Herrero, S., et al. 2020. Signal Transduct Target Ther. 5: 29. PMID: 32296045
6. C3G Is Upregulated in Hepatocarcinoma, Contributing to Tumor Growth and Progression and to HGF/MET Pathway Activation.  |  Sequera, C., et al. 2020. Cancers (Basel). 12: PMID: 32823931
7. Complex formation and reciprocal regulation between GSK3β and C3G.  |  Sriram, D., et al. 2021. Biochim Biophys Acta Mol Cell Res. 1868: 118964. PMID: 33450305
8. C3G self-regulatory mechanism revealed: implications for hematopoietic malignancies.  |  Carabias, A., et al. 2020. Mol Cell Oncol. 8: 1837581. PMID: 33553598
9. C3G down-regulation enhances pro-migratory and stemness properties of oval cells by promoting an epithelial-mesenchymal-like process.  |  Palao, N., et al. 2022. Int J Biol Sci. 18: 5873-5884. PMID: 36263169
10. Platelet C3G: a key player in vesicle exocytosis, spreading and clot retraction.  |  Fernández-Infante, C., et al. 2024. Cell Mol Life Sci. 81: 84. PMID: 38345631

The preferred C3G antibody is C3G Antibody (G-4): sc-17840.