
C3G Antibody (F-5) is a mouse monoclonal IgG1 antibody that detects C3G in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). C3G plays a crucial role as a guanine nucleotide exchange factor (GEF) for Ras, a key regulator in various cellular processes, including cell growth, differentiation, and survival. C3G (F-5) antibody helps researchers study how C3G activates Ras by facilitating the exchange of GDP for GTP, which is vital for proper cellular signaling; dysregulation of this process can lead to oncogenic transformations and contribute to cancer progression. Located in the cytoplasm, C3G interacts with the Crk proto-oncogene product, linking it to pathways that modulate Ras activity. The C3G gene is situated on human chromosome 9q34.13, near the c-Abl gene, which is also implicated in cancer. Anti-C3G antibody (F-5) serves as an essential tool for researchers studying the intricate mechanisms of Ras signaling and its implications in tumor biology, providing insights into potential therapeutic targets for cancer treatment.
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Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
C3G Antibody (F-5) | sc-376992 | 200 µg/ml | $322.00 | |||
C3G Antibody (F-5): m-IgG Fc BP-HRP Bundle | sc-540681 | 200 µg Ab; 10 µg BP | $361.00 | |||
C3G Antibody (F-5): m-IgG1 BP-HRP Bundle | sc-542295 | 200 µg Ab; 20 µg BP | $361.00 | |||
C3G (F-5) Neutralizing Peptide | sc-376992 P | 100 µg/0.5 ml | $69.00 |