HAUSP Antibody (G-10): sc-376912

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HAUSP (herpesvirus-associated ubiquitin-specific protease, USP7) is a ubiquitin-specific protease. HAUSP localizes predominantly to the nucleus, in a TD-dependent manner, where it associates with ND10 (1,2). ND10 are small nuclear structures implicated in a variety of cellular processes including response to stress and interferons, oncogenesis, and viral infection (2). HAUSP binds strongly to Vmw110, a herpesvirus regulatory protein which has the ability to disrupt ND10 (2,3). HAUSP, a novel p53-interacting protein, functions to deubiquitinize p53 in an important pathway for p53 stabilization (4,5). HAUSP strongly stabilizes p53 even in the presence of excess Mdm2, and also induces p53-dependent cell growth repression and apoptosis (4). The HAUSP protein is distributed in the nucleus in a micropunctate pattern with a limited number of larger discrete foci, some of which co-localize with PML in ND10 (6). The gene encoding HAUSP maps to human chromosome band 16p13.2 (5,6).