Welcome to Santa Cruz Biotechnology!
SCBT Home
Home » Membrane Receptors » ACTR Antibodies » ACTR-IC Antibody (D-11): sc-376905

ACTR-IC Antibody (D-11): sc-376905

 |  Datasheet

(Based on data analysis)

  • ACTR-IC Antibody (D-11) is a mouse monoclonal IgG2b provided at 200 µg/ml
  • raised against amino acids 38-169 mapping near the N-terminus of ACTR-IC of human origin
  • recommended for detection of ACTR-IC of human origin by WB, IP, IF and ELISA
 
Full-length ACTR-IC protein sequence with immunogen highlighted:
MTRALCSALRQALLLLAAAAELSPGLKCVCLLCDSSNFTCQTEGACWASVMLTNGKEQVIKSCVSLPELNAQVFCHSSNNVTKTECCFTDFCNNITLHLPTASPNAPKLGPMELAIIITVPVCLLSIAAMLTVWACQGRQCSYRKKKRPNVEEPLSECNLVNAGKTLKDLIYDVTASGSGSGLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIASGLAHLHMEIVGTQGKPAIAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQNPKVGTKRYMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYDMVPSDPSIEEMRKVVCDQKFRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKKTISQLCVKEDCKA

See additional ACTR Antibodies including ACTR, ACTR-I, ACTR-IA, ACTR-IB, ACTR-IC, ACTR-II, ACTR-IIA and ACTR-IIB.

Also see ACTR Inhibitors for functional analysis of cellular responses to ACTR.


Ordering InformationGene Info
Recommended Support Products:
(click button of application of choice)
WB   IP   IF  
Set Currency

 Ordering Information
Product NameCatalog #UnitPriceQtyAdd 
ACTR-IC Antibody (D-11) sc-376905 200 µg/ml $279
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human ACVR1C 130399 2q24.1 NM_001111031, NM_001111032, NM_001111033, NM_145259 Q8NER5
 608981
 

ACTR-IC (Activin receptor type 1C), also referred to as Activin receptor-like kinase 7 (ALK-7), is a type I serine/threonine kinase receptor. ACTA-IC contains an extracellular binding domain, an intracellular serine/threonine kinase domain preceded by a GS box and a transmembrane domain. It is expressed throughout the digestive and central nervous system and localizes to the cell surface. Four ACTR-IC transcripts are generated by alternative splicing. Transcript 1 is the functional full length receptor, transcript 2 lacks a complete receptor binding domain and transcripts 3 and 4 are soluble proteins that lack a transmembrane domain. ACTR-IC is a receptor for Activin AB, Activin B and Nodal. In pancreatic cells, ACTR-IC forms a complex with Activin receptor type IIB (ACTR-IIB). The kinase domain of ACTR-IC can induce Smad2 and Smad3 signalling pathways. In some cell lines, ACTR-IC overexpression induces apoptosis and inhibits proliferation.
ACTR-IC Antibody (D-11) Data
Click on image to enlarge
sc-376905
ACTR-IC (D-11): sc-376905. Western blot analysis of ACTR-IC expression in MIA PaCa-2 whole cell lysate.
Download
Datasheets
Get Adobe Acrobat Reader