TACC3 Antibody (E-4) | Santa Cruz Biotech

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TACC3 Antibody (E-4): sc-376900	\| Datasheet

5 5 (Based on data analysis) 1

TACC3 Antibody (E-4) is a mouse monoclonal IgG_2b provided at 200 µg/ml
specific for an epitope mapping between amino acids 45-83 within an internal region of TACC3 of human origin
recommended for detection of TACC3 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including canine and porcine

See additional TACC Antibodies including TACC, TACC1, TACC2 and TACC3.

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WB IP IF IHC(P)

Species	Gene Name	Gene ID	Chromosome Location	Isoform (mRNA) Accession #	Protein Accession #	OMIM™ Number

Human	TACC3	10460	4p16.3	NM_006342	Q9Y6A5	605303
Mouse	Tacc3	21335	5 B2	NM_001040435	Q9JJ11	N/A

TACC1 (transforming acidic coiled coil gene 1) is one of three TACC family members, which are thought to be involved in breast tumorigenesis. TACC1 is located on 8p11 chromosomal region that is amplified in approximately 15% of all breast tumor samples. The short arm of chromosome 8 also contains FGFR1 whose expression is enhanced in most breast cancer tumors. TACC family members, TACC1, TACC2, and TACC3, map very closely to the corresponding FGFR1, FGFR2, FGFR3 genes on chromosomes 8, 10, and 4. Subsequently, since they are phylogenetically related, it is proposed that TACC and FGFR have similar roles in cell growth and differentiation. Also, TACC1 contains a conserved C-terminal region as in the Drosophila homolog, D-TACC. It has been shown that D-TACC is necessary for normal spindle function, and the mammalian TACC proteins appears to interact with centrosomes and microtubules in a similar manner.

TACC3 Antibody (E-4) Data

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TACC3 (E-4): sc-376900. Western blot analysis of TACC3 expression in Jurkat whole cell lysate.

TACC3 (E-4): sc-376900. Immunoperoxidase staining of formalin fixed, paraffin-embedded human duodenum tissue showing cytoplasmic and membrane staining of glandular cells.

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TACC3 Antibody (E-4): sc-376900