TC-PTP Antibody (E-11): sc-376864

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T-cell protein tyrosine phosphatase (TC-PTP) is a non-transmembrane enzyme. The noncatalytic domain of TC-PTP is alternatively spliced to generate p45TC, which localizes to the nucleus, and p48TC, which contains a hydrophobic C-terminal tail and localizes to the ER. The C-terminal segment of p45TC regulates the activity of the catalytic domain through an intramolecular interaction. The p45TC variant of TC-PTP exits the nucleus upon EGF receptor activation and recognizes the EGF receptor and p52Shc cellular substrates. The p45TC activity almost completely inhibits the EGF-dependent activation of PI 3-kinase and PKB/Akt. In glioblastoma cells, the p45TC variant inhibits the DEGFR-mediated activation of ERK2 and suppresses tumorigenicity in vivo. TC-PTP may play a role in lymphoctye signaling and hematopoietic homeostasis. TC-PTP negatively regulates JAK1 and JAK3 and TC-PTP-deficient mice display gross defects in the hematopoietic system. The gene encoding human TC-PTP maps to chromosome 18.