Selenoprotein P Antibody (B-9): sc-376858

---

Selenium is an essential trace element that is incorporated as selenocysteine into the primary structure of selenoproteins. Nutritional deficiency of selenium decreases selenoprotein concentrations and leads to pathologic conditions. Most of the known selenoproteins are members of the glutathione peroxidase or iodothyronine deiodinase families. Selenoprotein P (SEPP1) is a major selenoprotein that is not a member of those families. It is an extracellular glycoprotein that is present in several isoforms and is the only selenoprotein known to contain multiple selenocysteine residues. Selenoprotein P is a heparin-binding protein that appears to be associated with endothelial cells and has been implicated as an oxidant defense in the extracellular space. Although there is evidence of several isoforms of the protein, all of them share the same amino-terminal sequence and therefore are likely products of the same gene. The gene which encodes Selenoprotein P maps to human chromosome 5q31.