PDE3B Antibody (F-9) | Santa Cruz Biotech

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PDE3B Antibody (F-9): sc-376823	\| Datasheet

5 5 (Based on data analysis) 1

PDE3B Antibody (F-9) is a mouse monoclonal IgM provided at 200 µg/ml
specific for an epitope mapping between amino acids 2-29 at the N-terminus of PDE3B of human origin
recommended for detection of PDE3B of human origin by WB, IP, IF, IHC(P) and ELISA

See additional PDE Antibodies including PDE, PDE1A, PDE1B, PDE1C, PDE6C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6 beta, PDE6A alpha, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PDE10A, PDE11A, PDE4A1, PDE4B1, PDE4A2, PDE4B2, PDE4B3, PDE4A5, PDE7A1, PDE7A2 and PDE7A3.

Also see PDE Inhibitors or PDE Activators for functional analysis of cellular responses to PDE.

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WB IP IF IHC(P)

Species	Gene Name	Gene ID	Chromosome Location	Isoform (mRNA) Accession #	Protein Accession #	OMIM™ Number

Human	PDE3B	5140	11p15.2	NM_000922	Q13370	602047

Phosphodiesterases (PDE, also designated cyclic nucleotide phosphodiesterase) are important for the downregulation of the intracellular level of the second messenger cyclic adenosine monophosphate (cAMP) by hydrolyzing cAMP to 5'AMP. Phosphodiesterase type 3 isoforms, PDE3A and 3B, are expressed primarily in cardiovascular tissue and adipose tissue, respectively. PDE3A, is found in myocardium and platelets and PDE3B is found in lymphocytes. The PDE7A1 (HCP1) isozyme and the PDE7A2 proteins, alternate splice products of PDE7A, are highly expressed in skeletal muscle. PDE7B is most highly expressed in pancreas. The PDE family contains proteins that serve tissue-specific roles in regulation of lipolysis, glycogenolysis, myocardial contractility, and smooth muscle relaxation.

PDE3B Antibody (F-9) Data

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PDE3B (F-9): sc-376823. Western blot analysis of PDE3B expression in Jurkat whole cell lysate.

PDE3B (F-9): sc-376823. Immunofluorescence staining of methanol-fixed HeLa cells showing cytoplasmic localization.

PDE3B (F-9): sc-376823. Immunoperoxidase staining of formalin fixed, paraffin-embedded human thyroid gland tissue showing cytoplasmic staining of glandular cells.

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PDE3B Antibody (F-9): sc-376823