TRB-2 Antibody (F-5): sc-376776

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TRB-2 (Tribbles homolog 2), also known as TRIB2, C5FW or GS3955, is a cytoplasmic pro-apoptotic protein that belongs to the Tribbles subfamily of the Serine/Threonine protein kinase family. Members of the Tribbles subfamily, namely TRB-1, TRB-2 and TRB-3, contain a protein kinase-like or TRB domain that lacks the active site lysine and does not appear to display kinase activity. TRB proteins are induced by mitogens and interact with and are stabilized by MAPKKs. TRB proteins play an important function in the MAP kinase pathway, as is demonstrated by the inhibition of MAPK signaling in response to both over and underexpression of TRB proteins. TRB-1 is widely expressed with highest levels found in bone marrow, pancreas, skeletal muscle, peripheral blood leukocytes and thyroid gland; TRB-2 is predominantly expressed in peripheral blood leukocytes; and TRB-3 is found at highest levels in pancreas, bone marrow and peripheral blood leukocytes.