Suppressin Antibody (A-7): sc-376477

Suppressin Antibody (A-7) is a mouse monoclonal IgG1 antibody that detects Suppressin in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Suppressin, also known as DEAF1, SPN, NUDR, or ZMYND5, is a crucial transcription factor involved in embryonic development, characterized by a unique structure including one SAND domain and one C-terminal MYND-type zinc finger. This structural configuration facilitates Suppressin′s interaction with other key regulatory proteins, such as LMO4 and CLIM-2, which are essential for mediating cell fate decisions and embryonic pattern formation. Suppressin is predominantly localized in the nucleus, where anti-Suppressin antibody (A-7) detects regulatory functions across various tissues, highlighting Suppressin′s importance in developmental biology. Alternative splicing of the Suppressin gene results in several isoforms, some of which can be secreted and play a role in inhibiting cell proliferation by arresting cells in the G0 or G1 phase. Mutations in the Suppressin gene may confer a growth advantage and contribute to neoplasia, underscoring Suppressin′s relevance as a target for cancer therapy. With versatile applications and a critical role in cellular processes, Suppressin (A-7) antibody serves as an invaluable tool for researchers studying developmental biology and cancer.

The preferred Suppressin antibody is Suppressin Antibody (E-5): sc-514180.