MSH2 Antibody (D-6): sc-376384

MSH2 Antibody (D-6) is a mouse monoclonal IgG1 kappa light chain antibody that detects MSH2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). MSH2 (D-6) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. MSH2 plays a critical role in the DNA mismatch repair (MMR) system, which is essential for maintaining genomic stability by correcting errors that occur during DNA replication. Deficiencies in this repair mechanism can lead to microsatellite instability, a hallmark of several cancers, including hereditary nonpolyposis colorectal cancer (HNPCC). MSH2′s importance extends beyond HNPCC, as studies have shown that 10 to 45% of various cancers, such as pancreatic, gastric, breast, ovarian, and small cell lung cancers, also exhibit microsatellite instability, indicating that MMR dysfunction may be a common feature in tumor initiation and progression. Additionally, the identification of additional homologs, PMS1 and PMS2, which are also implicated in MMR and mutated in HNPCC patients, underscores MSH2′s significance in cancer biology and highlights MSH2′s potential as a target for therapeutic intervention and diagnostic applications.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

MSH2 Antibody (D-6) References:

1. HDAC6 deacetylates and ubiquitinates MSH2 to maintain proper levels of MutSα.  |  Zhang, M., et al. 2014. Mol Cell. 55: 31-46. PMID: 24882211
2. MSH2 Dysregulation Is Triggered by Proinflammatory Cytokine Stimulation and Is Associated with Liver Cancer Development.  |  Eso, Y., et al. 2016. Cancer Res. 76: 4383-93. PMID: 27261510
3. Clinical significance of MLH1/MSH2 for stage II/III sporadic colorectal cancer.  |  Wang, SM., et al. 2019. World J Gastrointest Oncol. 11: 1065-1080. PMID: 31798786
4. Insertion of an SVA element in MSH2 as a novel cause of Lynch syndrome.  |  Yang, C., et al. 2021. Genes Chromosomes Cancer. 60: 571-576. PMID: 33822432
5. Cytoplasmic MSH2 Related to Genomic Deletions in the MSH2/EPCAM Genes in Colorectal Cancer Patients With Suspected Lynch Syndrome.  |  Dong, L., et al. 2021. Front Oncol. 11: 627460. PMID: 34055602
6. Analysis of the Expression and Prognostic Value of MSH2 in Pan-Cancer Based on Bioinformatics.  |  Qiu, W., et al. 2021. Biomed Res Int. 2021: 9485273. PMID: 34859104
7. Andrias davidianus Ranavirus (ADRV) Genome Replicate Efficiently by Engaging Cellular Mismatch Repair Protein MSH2.  |  Ke, F., et al. 2022. Viruses. 14: PMID: 35632694
8. Ataxia Telangiectasia Mutated and MSH2 Control Blunt DNA End Joining in Ig Class Switch Recombination.  |  Sible, E., et al. 2023. J Immunol. 210: 369-376. PMID: 36603026
9. Protein profiles reveal MSH6/MSH2 as a potential biomarker for hepatocellular carcinoma with microvascular invasion.  |  Hong, S., et al. 2024. Hepatol Res. 54: 189-200. PMID: 37776019
10. Muir-Torre Syndrome with Novel Mutation in the MSH2 Gene.  |  Ustaoglu, E., et al. 2023. Acta Dermatovenerol Croat. 31: 144-147. PMID: 38439724

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-MSH2 Antibody (D-6) has 5 citations in a variety of scientific publications.

Primary antibodies like Anti-MSH2 Antibody (D-6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

MSH2 Antibody (D-6) Specifications

Alternate Product Name: DNA Mismatch Repair Protein MSH2

Product Clone Name: D-6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-300

Epitope Target: MSH2

Epitope Species: human

Product Reactivity/Detection: MSH2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 5 citations in various scientific publications

Available Conjugates/Forms for MSH2 Antibody (D-6): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin