Kinectin 1 Antibody (G-5): sc-374576

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The kinesin family of motor proteins comprise at least two forms of conventional kinesin, which are encoded by different genes and designated as ubiquitous kinesin, which is expressed in all cells and tissues, and neuronal kinesin, which is expressed exclusively in neuronal cells (1,2). The motor protein kinesin is a heterotetramer composed of two heavy chains and two light chains (3,4). While the kinesin heavy chain contains the motor activity, evidence suggests that the kinesin light chain is involved in either modulation of kinesin heavy chain activity or in cargo binding (5). Kinesin-driven vesicle motility is dependent upon kinectin 1, a kinesin-binding protein (6). Kinectin 1, also known as kinesin receptor, is an integral membrane protein in the ER (7–9). Despite the kinesin-kinectin 1 interaction, a great deal of debate surrounds the involvement of kinectin 1 in microtubule-dependent transport (2,10).