HNMT Antibody (D-5): sc-374306

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Histamine is a biogenic amine that functions as a neurotransmitter in the gut and plays an important role in the immune system, specifically by dilating blood vessels in response to allergic reactions. HNMT (Histamine N-methyltransferase), also known as HMT, HNMT-S1 or HNMT-S2, is a 292 amino acid protein that exists as a monomer and belongs to the methyltransferase superfamily. Localized to the cytoplasm, HNMT catalytically inactivates histamine by N-methylation and, via this inactivation, plays an essential role in the degradation of histamine. Through its ability to regulate and reduce the amount of histamine within the cell, HNMT participates in the airway response and limits the severity of allergic reactions. A common genetic polymorphism in HNMT may be linked to a predisposition to asthma. HNMT is expressed as multiple isoforms due to alternative splicing events.