Aldose Reductase Antibody (E-12): sc-373953

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Aldose reductase (designated ALR2) is member of the monomeric NADPH-dependent aldoketoreductase family. ALR2 catalyzes the reduction of various aldehydes and has been implicated in the development of diabetic complications by catalyzing the reduction of the aldehyde form of glucose, to the corresponding sugar alcohol, sorbitol. This pathway plays a minor role in glucose metabolism in most tissues, however in diabetic hyperglycemia, cells undergoing insulin-independent uptake of glucose accumulate significant quantities of sorbitol. The resulting hyperosmotic stress to cells may be a cause of diabetic complications such as neuropathy, retinopathy, and cataracts. Aldose reductase is very similar to human aldehyde reductase (designated ALR1), bovine prostaglandin F synthase and to the European common frog protein, rho-crystallin.