E-FABP Antibody (D-12): sc-373788

E-FABP Antibody (D-12) is a mouse monoclonal IgG1 antibody that detects E-FABP in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). E-FABP, or epithelial fatty acid-binding protein, is a crucial member of the fatty acid-binding protein family, which is known for its role in lipid metabolism and cellular signaling. E-FABP is primarily located in the cytoplasm of keratinocytes and plays a significant role in keratinocyte differentiation, making E-FABP essential for maintaining skin integrity and function. E-FABP binds to fatty acids, particularly stearic acid, facilitating their transport and utilization within the cell. E-FABP′s function is highlighted by E-FABP upregulation in response to nerve injury, as observed in rat dorsal root ganglia after sciatic nerve crush, indicating E-FABP′s potential involvement in neuronal development and repair processes. Anti-E-FABP antibody (D-12) is an invaluable tool for researchers studying lipid metabolism, skin biology, and neuronal differentiation, providing insights into the complex mechanisms that govern cellular responses to fatty acids.

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E-FABP Antibody (D-12) References:

1. Probable interaction between S100A7 and E-FABP in the cytosol of human keratinocytes from psoriatic scales.  |  Hagens, G., et al. 1999. Mol Cell Biochem. 192: 123-8. PMID: 10331666
2. Solution structure and backbone dynamics of human epidermal-type fatty acid-binding protein (E-FABP).  |  Gutiérrez-González, LH., et al. 2002. Biochem J. 364: 725-37. PMID: 12049637
3. Metastasis of squamous cell carcinoma of the oral tongue is associated with down-regulation of epidermal fatty acid binding protein (E-FABP).  |  Uma, RS., et al. 2007. Oral Oncol. 43: 27-32. PMID: 16759896
4. Expression of E-FABP in PC12 cells increases neurite extension during differentiation: involvement of n-3 and n-6 fatty acids.  |  Liu, JW., et al. 2008. J Neurochem. 106: 2015-29. PMID: 18513372
5. Effects of intermittent hypoxia on A-/E-FABP expression in human aortic endothelial cells.  |  Han, Q., et al. 2010. Int J Cardiol. 145: 396-398. PMID: 20452069
6. E-FABP induces differentiation in normal human keratinocytes and modulates the differentiation process in psoriatic keratinocytes in vitro.  |  Dallaglio, K., et al. 2013. Exp Dermatol. 22: 255-61. PMID: 23528210
7. Fatty acid-binding protein E-FABP restricts tumor growth by promoting IFN-β responses in tumor-associated macrophages.  |  Zhang, Y., et al. 2014. Cancer Res. 74: 2986-98. PMID: 24713431
8. Dietary Fats High in Linoleic Acids Impair Antitumor T-cell Responses by Inducing E-FABP-Mediated Mitochondrial Dysfunction.  |  Jin, R., et al. 2021. Cancer Res. 81: 5296-5310. PMID: 34400394
9. Septoclasts expressing epidermal fatty acid-binding protein (E-FABP, FABP5) in endochondral ossification.  |  Bando, Y., et al. 2022. J Oral Biosci. 64: 18-25. PMID: 34915120
10. Skin-derived antileukoproteinase (SKALP) and epidermal fatty acid-binding protein (E-FABP): two novel markers of the psoriatic phenotype that respond differentially to topical steroid.  |  Kuijpers, AL., et al. 1997. Acta Derm Venereol. 77: 14-9. PMID: 9059669

The preferred E-FABP antibody is E-FABP Antibody (A-9): sc-365236.