Pez Antibody (F-12): sc-373766

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Pez (protein tyrosine phosphatase Pez), also known as PTP36 or Tyrosine-protein phosphatase non-receptor type 14 (PTPN14), is a member of the non-receptor class subfamily of the protein tyrosine phosphatase family. Protein tyrosine phosphatases (PTPs) are involved in the regulation of a variety of cellular processes. Pez is a cytosolic protein (concentrated at the intercellular junctions) that is expressed in various tissues including placenta, lung, kidney and skeletal muscle. It contains one protein tyrosine phosphatase domain and one FERM (4.1, ezrin, radixin, moesin) domain. In actively proliferating cells, where cell-cell contacts have been disrupted, Pez translocates to the nucleus. TGF∫, a protein known to inhibit cell proliferation, can inhibit the nuclear translocation of Pez. Localization of Pez is also regulated by serum concentrations; higher serum concentrations can lead to the accumulation of Pez in the nucleus. This strongly suggests a role for Pez in cell proliferation.