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home » Transcription Regulators » I kappa B Antibody / I kappa B Antibodies » IκB-α (C-21): sc-371

IκB-α (C-21) Antibody: sc-371

  |  Datasheet
  • rabbit polyclonal IgG, 200 µg/ml; also available as goat IgG, 200 µg/ml, sc-371-G
  • epitope mapping at the C-terminus of IκB-α of human origin
  • recommended for detection of IκB-α of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
  • blocking peptide, sc-371 P
  • agarose conjugate for IP studies, sc-371 AC, 500 µg/0.25 ml agarose
  • fluorescein (sc-371 FITC) and rhodamine (sc-371 TRITC) conjugates for immunofluorescence, 200 µg/ml
  • Alexa Fluor® 405 (sc-371 AF405), Alexa Fluor® 488 (sc-371 AF488) and Alexa Fluor® 647 (sc-371 AF647) conjugates for immunofluorescence; 100 µg/2 ml
 
Additional I kappa B Antibodies ...
 
Ordering InformationProduct Citations
Recommended Support Products:
(click button of application of choice)
WB   IP   IF   IHC(P)   siRNA  
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human NFKBIA 4792 14q13.2 NM_020529 P25963
 164008
Human NFKBIA 4792 14q13.2 P25963
 164008
Mouse Nfkbia 18035 12 C1 Q9Z1E3
 N/A
Mouse Nfkbia 18035 12 C1 Q9Z1E3
 N/A
 
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 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
IκB-α (C-21) sc-371 200 µg/ml $279
IκB-α (C-21) AC sc-371 AC 500µg/ml, 25%ag $366
IκB-α (C-21) Alexa Fluor® 405 sc-371 AF405 100 µg/2 ml $314
IκB-α (C-21) Alexa Fluor® 488 sc-371 AF488 100 µg/2 ml $314
IκB-α (C-21) Alexa Fluor® 647 sc-371 AF647 100 µg/2 ml $314
IκB-α (C-21) FITC sc-371 FITC 200 µg/ml $282
IκB-α (C-21) P sc-371 P
(peptide)
 100 µg/0.5 ml $61
IκB-α (C-21) TRITC sc-371 TRITC 200 µg/ml $282
IκB-α (C-21)-G sc-371-G 200 µg/ml $279
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
IκB-α siRNA (h) sc-29360 10 µM $258
IκB-α siRNA (m) sc-29361 10 µM $258
IκB-α siRNA (h2) sc-44265 10 µM $258
IκB-α (h)-PR sc-29360-PR 10 µM $23
IκB-α (m)-PR sc-29361-PR 10 µM $23
IκB-α (h2)-PR sc-44265-PR 10 µM $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
IκB-α shRNA Plasmid (h) sc-29360-SH 20 µg $520
IκB-α shRNA Plasmid (m) sc-29361-SH 20 µg $520
IκB-α shRNA Plasmid (h2) sc-44265-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
IκB-α shRNA (h) Lentiviral Particles sc-29360-V 200 µl $625
IκB-α shRNA (m) Lentiviral Particles sc-29361-V 200 µl $625
IκB-α shRNA (h2) Lentiviral Particles sc-44265-V 200 µl $625
 WB Positive Control Cell Lysates (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
HeLa Whole Cell Lysate sc-2200 500 µg/200 µl $104
Jurkat Whole Cell Lysate sc-2204 500 µg/200 µl $104
A-431 Whole Cell Lysate sc-2201 500 µg/200 µl $104
HL-60 Whole Cell Lysate sc-2209 500 µg/200 µl $104
NIH/3T3 Whole Cell Lysate sc-2210 500 µg/200 µl $104
KNRK Whole Cell Lysate sc-2214 500 µg/200 µl $104
 WB Control Recombinant Protein (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
IκB-α (1-317) sc-4094 50 µg $167

IκB-α Background Information
On the basis of both functional and structural considerations, members of the I˚B family of proteins can be divided into four groups. The first of these groups, I˚B-å, includes the avian protein pp40 and the mammalian MAD-3, both of which inhibit binding of p50-p65 NFkB complex or Rel protein to their cognate binding sites but do not inhibit the binding of p50 homodimer to ˚B sites, suggesting that the I˚B-å family binds to the p65 subunit of p50-p65 heterocomplex through ankyrin repeats. The second member of the I˚B family is represented by a protein designated I˚B-∫. The third group of I˚B proteins is represented by I˚B-©, which is identical in sequence with the C-terminal domain of the p110 precursor of NFkB p50 and is expressed predominantly in lymphoid cells. An additional I˚B family member, I˚B-é, has several phosphorylated forms and is primarily found complexed with Rel A and/or c-Rel.

IκB-α (C-21) Product Citations
See how others have used IκB-α (C-21): sc-371 antibody and or IκB-α (C-21) antibody conjugates.


644 total citations
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Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
 
IκB-α (C-21)
Click on image to enlarge
sc-371
IκB-α (C-21): sc-371. Western blot analysis of IκB-α expression in HeLa (A), Jurkat (B), A-431 (C), HL-60 (D), NIH/3T3 (E) and KNRK (F) whole cell lysates.
sc-371
IκB-α (C-21)-G: sc-371-G. Western blot analysis of IκB-α expression in HeLa (A), Jurkat (B) and A-431 (C) whole cell lysates.
sc-371
IκB-α (C-21): sc-371. Immunofluorescence staining of methanol-fixed HeLa cells showing cytoplasmic localization.
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