epitope mapping at the C-terminus of Bcl-6 of human origin
recommended for detection of Bcl-6 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
blocking peptide, sc-368 P
TransCruz reagent for Gel Supershift and ChIP applications, sc-368 X, 200 µg/0.1 ml
Bcl-6 Background Information Bcl-6, a transcriptional repressor, binds Stat recognition-like DNA elements and influences germinal center development and Th1/Th2 differentiation. Bcl-6 negatively regulates NFkB expression, thereby inhibiting NFkB-mediated cellular functions. HDAC- and silent information regulator (SIR)-2-dependent acet-ylation of Bcl-6 causes downregulation of activity by inhibiting the ability of Bcl-6 to recruit complexes containing histone deacetylases (HDACs). Bcl-6 is frequently deregulated in non-Hodgkin’s B cell lymphomas. The human BCL6 gene has been shown to encode a protein of 706 amino acids.
Bcl-6 (C-19) Product Citations
See how others have used Bcl-6 (C-19): sc-368 antibody and or Bcl-6 (C-19) antibody conjugates.
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Bcl-6 (C-19)
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Bcl-6 (C-19): sc-368. Western blot analysis of Bcl-6 expression in Ramos (A) and NAMALWA (B) whole cell lysates.
Bcl-6 (C-19): sc-368. Western blot analysis of Bcl-6 expression in non-transfected: sc-117752 (A) and mouse Bcl-6 transfected: sc-118780 (B) 293T whole cell lysates.
Bcl-6 (C-19): sc-368. Western blot analysis of Bcl-6 expression in non-transfected: sc-117752 (A) and human Bcl-6 transfected: sc-112850 (B) 293T whole cell lysates.
Bcl-6 (C-19): sc-368. Immunofluorescence staining of methanol-fixed Hep G2 cells showing nuclear and cytoplasmic localization.
