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p-PKC δ Antibody (F-7): sc-365969

 |  Datasheet

(Based on data analysis)

  • p-PKC δ Antibody (F-7) is a mouse monoclonal IgG3 provided at 200 µg/ml
  • epitope corresponding to a short amino acid sequence containing phosphorylated Thr 507 of PKC δ of human origin
  • recommended for detection of Thr 507 phosphorylated PKC δ of mouse, rat and human origin by WB, IP, IF and ELISA
 

See additional PKC Antibodies including PKC, PKC alpha, PKC beta, PKC delta, PKC epsilon, PKC eta, PKC gamma, PKC iota, PKC lambda, PKC mu, PKC nu, PKC theta, PKC zeta and Pkc1.

Also see PKC delta Inhibitors or PKC delta Substrates for functional analysis of cellular responses to PKC delta.


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p-PKC δ Antibody (F-7) sc-365969 200 µg/ml $279

Members of the protein kinase C (PKC) family play a key regulatory role in a variety of cellular functions, including cell growth and differentiation, gene expression, hormone secretion and membrane function (1,2). PKCs were originally identified as serine/threonine protein kinases whose activity was dependent on calcium and phospholipids (3). Diacylglycerols (DAG) and tumor promoting phorbol esters bind to and activate PKC (4,5). PKCs can be subdivided into at least two major classes, including conventional (c) PKC isoforms (å, ∫I, ∫II and ©) and novel (n) PKC isoforms (∂, é , Ω, h and †) (6). PKC isoforms can be activated through tyrosine phosphorylation and catalytically activated upon treatment with H2O2 (7,8). The Tyr 155, 525, 523 and 565 residues in the catalytic domain are crucial for activation of these enzymes (7,8). The residue Ser 643 appears to be an autophosphorylation site (9).
p-PKC δ Antibody (F-7) Data
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sc-365969
Western blot analysis of PKC δ phosphorylation in untreated (A,C) and lambda protein phosphatase (sc-200312A) treated (B,D) RAW 264.7 whole cell lysates. Antibodies tested include p-PKC δ (F-7): sc-365969 (A,B) and PKC δ (C-20): sc-937 (C,D).
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