p-MBP Antibody (D-11) | Santa Cruz Biotech

Welcome to Santa Cruz Biotechnology!

Research Products
Primary Antibodies: Mammalian Phospho-Specific Antibodies Antibodies for IHC (Paraffin) Staining Flow Cytometry Veterinary Research Antibodies Primary Antibodies: Non-Mammalian siRNA and shRNA (plasmid and lentivirus) Products Protein A, G PLUS and L-Agarose Tissue Extracts and Cell Lysates Biologically Active and Purified Proteins Transfected Cell Lysates Secondary Antibodies, Control Antibodies and Normal Sera Specialty Reagents and Kits
Chemicals
Biochemicals Prepared Buffers Buffer Components and Standard Lab Chemicals Stains Dyes and Fluorescent Probes Solvents HRP and AP Substrates
Lab Supplies
Animal Health
Animal Health Promo Animal Health Book Promo Animal Health News Animal Health Pharmacy Ultra Cruz Supplements
What's New
Promotionals LIF Protein Veterinary Research Antibodies Monoclonal Antibodies New IHC (Paraffin) Staining
Information
Contact Us Order Information Cruz Credits™ Investigator Awards Job Opportunities Distributors
Support
Protocols Product Citations Datasheets / MSDS Technical Service Catalog Request Chromosome DBase

p-MBP Antibody (D-11): sc-365621	\| Datasheet

5 5 (Based on data analysis) 1

p-MBP Antibody (D-11) is a mouse monoclonal IgG₃ provided at 200 µg/ml
epitope corresponding to a short amino acid sequence containing phosphorylated Thr 125 of MBP of human origin
recommended for detection of Thr 125 phosphorylated MBP of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA

See additional Myelin Basic Protein Antibodies.

Ordering InformationGene Info

Recommended Support Products:

(click button of application of choice)

WB IP IF IHC(P)

Ordering Information

Product Name	Catalog #	Unit	Price	Qty	Add
p-MBP Antibody (D-11)	sc-365621	200 µg/ml	$279

Species	Gene Name	Gene ID	Chromosome Location	Isoform (mRNA) Accession #	Protein Accession #	OMIM™ Number

Human	MBP	4155	18q22.3	NM_001025081, NM_001025090, NM_001025092, NM_001025100, NM_001025101, NM_002385	P02686	159430
Mouse	Mbp	17196	18 E3	NM_001025245, NM_001025251, NM_001025254, NM_001025255, NM_001025256, NM_001025258, NM_001025259, NM_010777	P04370	N/A

Myelin basic protein (MBP) is the major extrinsic membrane protein of central nervous system myelin. Myelin basic protein phosphorylation at Threonine 125 is a complex regulatory process that modulates the contribution of MBP to the stability of the myelin sheath. Mitogen-activated protein kinases modulate MBP phosphorylation during myelinogenesis and in the demyelinating disease multiple sclerosis. MBP phosphorylation is regulated by high-frequency stimulation but not low-frequency stimulation of the alveus, the myelinated output fibers of the hippocampus. It is proposed that during periods of increased neuronal activity, calcium activates axonal nitric oxide synthase, which generates the intercellular messengers nitric oxide and superoxide and regulates the phospho-rylation state of MBP by MAPK.

p-MBP Antibody (D-11) Data

Click on image to enlarge

p-MBP (D-11): sc-365621. Immunoperoxidase staining of formalin fixed, paraffin-embedded human brain tissue showing cytoplasmic staining of neuronal cells and nerve fibers.

Western blot analysis of MBP phosphorylation in untreated (A,C) and lambda protein phosphatase (sc-200312A) treated (B,D) rat brain tissue extract. Antibodies tested include p-MBP (D-11): sc-365621 (A,B) and MBP (BM15): sc-52070 (C,D).

Western blot analysis of MBP phosphorylation in untreated (A,C) and lambda protein phosphatase (sc-200312A) treated (B,D) rat cerebellum tissue extract. Antibodies tested include p-MBP (D-11): sc-365621 (A,B) and MBP (BM15): sc-52070 (C,D).

Download

Datasheets

Get Adobe Acrobat Reader

p-MBP Antibody (D-11): sc-365621