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CARD 9 Antibody (F-4): sc-365545

 |  Datasheet

(Based on data analysis)

  • CARD 9 Antibody (F-4) is a mouse monoclonal IgG2a provided at 200 µg/ml
  • raised against amino acids 98-187 mapping within an internal region of CARD 9 of human origin
  • recommended for detection of CARD 9 of human origin by WB, IP, IF and ELISA
 
Full-length CARD 9 protein sequence with immunogen highlighted:
MSDYENDDECWSVLEGFRVTLTSVIDPSRITPYLRQCKVLNPDDEEQVLSDPNLVIRKRKVGVLLDILQRTGHKGYVAFLESLELYYPQLYKKVTGKEPARVFSMIIDASGESGLTQLLMTEVMKLQKKVQDLTALLSSKDDFIKELRVKDSLLRKHQERVQRLKEECEAGSRELKRCKEENYDLAMRLAHQSEEKGAALMRNRDLQLEIDQLKHSLMKAEDDCKVERKHTLKLRHAMEQRPSQELLWELQQEKALLQARVQELEASVQEGKLDRSSPYIQVLEEDWRQALRDHQEQANTIFSLRKDLRQGEARRLRCMEEKEMFELQCLALRKDSKMYKDRIEAILLQMEEVAIERDQAIATREELHAQHARGLQEKDALRKQVRELGEKADELQLQVFQCEAQLLAVEGRLRRQQLETLVLSSDLEDGSPRRSQELSLPQDLEDTQLSDKGCLAGGGSPKQPFAALHQEQVLRNPHDAGLSSGEPPEKERRRLKESFENYRRKRALRKMQKGWRQGEEDRENTTGSDNTDTEGS

See additional CARD Antibodies including CARD, CARD 17, CARD 6, CARD 8, CARD 9, CARD 10, CARD 11, CARD 12 and CARD 14.

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 Ordering Information
Product NameCatalog #UnitPriceQtyAdd 
CARD 9 Antibody (F-4) sc-365545 200 µg/ml $279
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human CARD9 64170 9q34.3 NM_052813, NM_052814 Q9H257
 607212
Mouse Card9 332579 2 A3 NM_001037747 NP_001032836
 N/A
 

Membrane-associated guanylate kinase (MAGUK) family members localize to the plasma membrane and function as molecular scaffolds for the assembly of multi-protein complexes. The MAGUK family includes several mammalian proteins related to the Drosophila tumor suppressor discs-large (dlg) gene product such as postsynaptic proteins, GKAPs, the tight junction associated proteins (ZO-1-3), and the caspase-associated recruitment domain (CARD) proteins: CARD 6, CARD 8-12 and CARD 14. CARD 9 is the main transducer of Dectin-1 signals that consist of mediated myeloid cell activation, cytokine production, and innate anti-fungal immunity. Dectin-1 is the main mammalian receptor that recognizes the fungal component zymosan. CARD 9 self-associates and has coiled-coil motifs that may function as oligomerization domains. Bcl10 interacts with CARD 9 and regulates the zymosan induced NF-˚B activation. Overexpression of CARD 9 correlates with the development of gastric B-cell lymphoma.
CARD 9 Antibody (F-4) Data
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sc-365545
CARD 9 (F-4): sc-365545. Western blot analysis of CARD 9 expression in non-transfected: sc-110760 (A) and human CARD 9 transfected: sc-174094 (B) 293 whole cell lysates.
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