GPI-PLD Antibody (E-8): sc-365037

GPI-PLD Antibody (E-8) is a mouse monoclonal IgG2a antibody that detects phosphatidylinositol-glycan-specific phospholipase D (GPI-PLD) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). GPI-PLD plays a crucial role in lipid metabolism by hydrolyzing the inositol phosphate linkage in proteins anchored by phosphatidylinositol-glycans, which are important for various cellular functions, including cell signaling and membrane dynamics. GPI-PLD is predominantly found in serum, liver, cerebrospinal fluid, and milk, where GPI-PLD associates with specific lipoproteins containing apolipoproteins A-I and A-IV. Notably, serum GPI-PLD activity is significantly reduced in conditions such as systemic inflammatory response syndrome, suggesting GPI-PLD may be integral to regulating proinflammatory responses. The ability of GPI-PLD to modulate inflammation highlights GPI-PLD′s potential as a biomarker for inflammatory diseases and a target for therapeutic interventions. Anti-GPI-PLD antibody (E-8) is an essential tool for researchers investigating the role of GPI-PLD in health and disease.

The preferred GPI-PLD antibody is GPI-PLD Antibody (D-10): sc-365096.