See product citations (67)
QUICK LINKS
MK-2206 dihydrochloride is a highly selective inhibitor of Akt1, Akt2 and Akt3 with IC50 values of 8 nM, 12 nM and 65 nM, respectively. It is an allosteric inhibitor and is activated by the pleckstrin homology domain. MK-2206 dihydrochloride inhibits auto-phosphorylation of both Akt T308 and S473. It also prevents Akt-mediated phosphorylation of downstream signaling molecules, including TSC2, PRAS40 and ribosomal S6 proteins. Additionally, it shows synergistic responses in combination with cytotoxic agents such as Erlotinib (sc-202154) or Lapatinib (sc-353658) in lung NCI-H460 or ovarian A2780 tumor cells. MK-2206 dihydrochloride inhibits the nasopharyngeal carcinoma (NPC) cell lines CNE-1, CNE-2, HONE-1, and SUNE-1 proliferation in dose- and time-dependent manner. MK-2206 dihydrochloride is also known as MK2206, MK 2206, MK-2206 2HCl, and 8-[4-(1-aminocyclobutyl)phenyl]-9-phenyl-2H-[1,2,4]triazolo[3,4-f][1,6]naphthyridin-3-onedihydrochloride.
Ordering Information
Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MK-2206 dihydrochloride, 5 mg | sc-364537 | 5 mg | $178.00 | |||
MK-2206 dihydrochloride, 10 mg | sc-364537A | 10 mg | $325.00 |