Molecular structure of trans-Ned 19, CAS Number: 1354235-96-3
trans-Ned 19 (CAS 1354235-96-3)
See product citations (3)
Alternate Names:
trans-Ned 19 is known as an NAADP antagonist.
Application:
trans-Ned 19 is a Ca2+ release inhibitor and antagonist of nicotinic acid adenine dinucleotide phosphate (NAADP).
CAS Number:
1354235-96-3
Purity:
≥98%
Molecular Weight:
514.59
Molecular Formula:
C30H31FN4O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
trans-Ned 19 is a fluorescent label for NAADP receptors in intact cells. trans-Ned 19 also inhibits the release of Ca2+. NAADP binding is also inhibited (IC50 = 0.4 nM) by trans-Ned 19. trans-Ned 19 is cell-permeable, making it an excellent probe.
trans-Ned 19 (CAS 1354235-96-3) References
- P2Y receptor subtypes evoke different Ca2+ signals in cultured aortic smooth muscle cells. | Govindan, S. and Taylor, CW. 2012. Purinergic Signal. 8: 763-77. PMID: 22767215
- NAADP and the two-pore channel protein 1 participate in the acrosome reaction in mammalian spermatozoa. | Arndt, L., et al. 2014. Mol Biol Cell. 25: 948-64. PMID: 24451262
- Arachidonic acid activates release of calcium ions from reticulum via ryanodine receptor channels in C2C12 skeletal myotubes. | Muslikhov, ER., et al. 2014. Biochemistry (Mosc). 79: 435-9. PMID: 24954594
- Two-Pore Channel 2 activity is required for slow muscle cell-generated Ca(2+) signaling during myogenesis in intact zebrafish. | Kelu, JJ., et al. 2015. Int J Dev Biol. 59: 313-25. PMID: 26679948
- Structure, inhibition and regulation of two-pore channel TPC1 from Arabidopsis thaliana. | Kintzer, AF. and Stroud, RM. 2016. Nature. 531: 258-62. PMID: 26961658
- Ca2+ release via two-pore channel type 2 (TPC2) is required for slow muscle cell myofibrillogenesis and myotomal patterning in intact zebrafish embryos. | Kelu, JJ., et al. 2017. Dev Biol. 425: 109-129. PMID: 28390800
- Involvement of two-pore channels in hydrogen peroxide-induced increase in the level of calcium ions in the cytoplasm of human umbilical vein endothelial cells. | Avdonin, PV., et al. 2017. Dokl Biochem Biophys. 474: 209-212. PMID: 28726088
- The Role of Two-Pore Channels in Norepinephrine-Induced [Ca2+]i Rise in Rat Aortic Smooth Muscle Cells and Aorta Contraction. | Trufanov, SK., et al. 2019. Cells. 8: PMID: 31557916
- Quercetin depletes intracellular Ca2+ stores and blunts ATP-triggered Ca2+ signaling in bEnd.3 endothelial cells. | Chen, CY., et al. 2020. Fundam Clin Pharmacol. 34: 213-221. PMID: 31618480
- TPC2-mediated Ca2+ signaling is required for axon extension in caudal primary motor neurons in zebrafish embryos. | Guo, C., et al. 2020. J Cell Sci. 133: PMID: 32546534
- A DNA-based voltmeter for organelles. | Saminathan, A., et al. 2021. Nat Nanotechnol. 16: 96-103. PMID: 33139937
- Intestinal goblet cells sample and deliver lumenal antigens by regulated endocytic uptake and transcytosis. | Gustafsson, JK., et al. 2021. Elife. 10: PMID: 34677124
- Trans-Ned 19-Mediated Antagonism of Nicotinic Acid Adenine Nucleotide-Mediated Calcium Signaling Regulates Th17 Cell Plasticity in Mice. | Nawrocki, M., et al. 2021. Cells. 10: PMID: 34831261
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
trans-Ned 19, 10 mg | sc-362814 | 10 mg | $332.00 |