Molecular structure of ICA 069673, CAS Number: 582323-16-8
ICA 069673 (CAS 582323-16-8)
Application:
ICA 069673 is a selective activator of the KCNQ2/Q3 potassium channel
CAS Number:
582323-16-8
Molecular Weight:
269.63
Molecular Formula:
C11H6ClF2N3O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
ICA 069673 is a potassium channel opener with selective action for KCNQ2 and KCNQ3 (EC50=0.69 μM). No meeasurable activity was displayed over a variety of cardiac ion channels.
ICA 069673 (CAS 582323-16-8) References
- Differential activation of vascular smooth muscle Kv7.4, Kv7.5, and Kv7.4/7.5 channels by ML213 and ICA-069673. | Brueggemann, LI., et al. 2014. Mol Pharmacol. 86: 330-41. PMID: 24944189
- The Novel KV7.2/KV7.3 Channel Opener ICA-069673 Reveals Subtype-Specific Functional Roles in Guinea Pig Detrusor Smooth Muscle Excitability and Contractility. | Provence, A., et al. 2015. J Pharmacol Exp Ther. 354: 290-301. PMID: 26087697
- Effects of novel subtype selective M-current activators on spinal reflexes in vitro: Comparison with retigabine. | Vicente-Baz, J., et al. 2016. Neuropharmacology. 109: 131-138. PMID: 27263036
- Targeting Kv7 channels in pain pathways. | Rivera-Arconada, I., et al. 2017. Oncotarget. 8: 12554-12555. PMID: 28199957
- Four drug-sensitive subunits are required for maximal effect of a voltage sensor-targeted KCNQ opener. | Wang, AW., et al. 2018. J Gen Physiol. 150: 1432-1443. PMID: 30166313
- Chemical regulation of Kv7 channels: Diverse scaffolds, sites, and mechanisms of action. | Kurata, HT. 2020. J Gen Physiol. 152: PMID: 32484852
- Heteromeric Assembly of Truncated Neuronal Kv7 Channels: Implications for Neurologic Disease and Pharmacotherapy. | Li, J., et al. 2020. Mol Pharmacol. 98: 192-202. PMID: 32580997
- Functional and behavioral signatures of Kv7 activator drug subtypes. | Kanyo, R., et al. 2020. Epilepsia. 61: 1678-1690. PMID: 32652600
- Detrusor Smooth Muscle KV7 Channels: Emerging New Regulators of Urinary Bladder Function. | Malysz, J. and Petkov, GV. 2020. Front Physiol. 11: 1004. PMID: 33041840
- Familial neonatal seizures caused by the Kv7.3 selectivity filter mutation T313I. | Maghera, J., et al. 2020. Epilepsia Open. 5: 562-573. PMID: 33336127
- Chemical modulation of Kv7 potassium channels. | Borgini, M., et al. 2021. RSC Med Chem. 12: 483-537. PMID: 34046626
- Synthetic resin acid derivatives selectively open the hKV 7.2/7.3 channel and prevent epileptic seizures. | Ottosson, NE., et al. 2021. Epilepsia. 62: 1744-1758. PMID: 34085706
- Kv7 Channels in Cyclic-Nucleotide Dependent Relaxation of Rat Intra-Pulmonary Artery. | Al-Chawishly, M., et al. 2022. Biomolecules. 12: PMID: 35327621
- Kv7-specific activators hyperpolarize resting membrane potential and modulate human iPSC-derived sensory neuron excitability. | Estacion, M., et al. 2023. Front Pharmacol. 14: 1138556. PMID: 36923357
Activator of:
KCNQ2, and KCNQ3.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ICA 069673, 10 mg | sc-362745 | 10 mg | $159.00 | |||
ICA 069673, 50 mg | sc-362745A | 50 mg | $645.00 |