Dalfopristin (as mesylate) (CAS 112362-50-2)

Dalfopristin, as mesylate, is a potent antibiotic compound that has attracted significant attention in scientific research due to its unique mechanism of action and potential applications in microbiology and drug discovery. Mechanistically, dalfopristin disrupts bacterial protein synthesis by binding to the 50S ribosomal subunit, specifically at the ribosomal exit tunnel. This binding interferes with the elongation phase of translation, preventing the addition of amino acids to the growing peptide chain. Dalfopristin′s mechanism of action is distinct from other antibiotics, making it effective against a wide range of gram-positive bacteria, including multidrug-resistant strains such as methicillin-resistant Staphylococcus aureus (MRSA). In research, dalfopristin has been instrumental in elucidating the structural and functional properties of the bacterial ribosome, providing insights into the molecular basis of antibiotic activity and bacterial resistance mechanisms. Moreover, dalfopristin has been used as a tool in biotechnological applications, such as protein synthesis studies and recombinant DNA technology. Its ability to selectively target bacterial ribosomes has made it valuable in understanding bacterial physiology and pathogenesis. Furthermore, ongoing research explores the potential of dalfopristin and its derivatives in developing novel antimicrobial agents and combating antibiotic resistance. Overall, dalfopristin continues to be a valuable asset in scientific research, offering insights into bacterial biology and providing tools for biotechnological advancements.