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CP 471474 (CAS 210755-45-6)

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Synonym:2-[[[4-(4-Fluorophenoxy)phenyl]sulfonyl]amino]-N-hydrox y-2-methylpropanamide; PF-1626077
Application:A matrix metalloprotease (MMP) inhibitor
CAS Number:210755-45-6
Molecular Weight:368.38
Molecular Formula:C16H16FN2O5S
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Product NameCatalog #UnitPriceQtyAdd 
CP 471474 sc-361157 10 mg $200
Description
Broad spectrum MMP inhibitor (IC50 values are 0.7, 0.9, 13, 16 and 1170 nM for MMP-2, MMP-13, MMP-9, MMP-3 and MMP-1 respectively).
Technical Information
Appearance:Off-white
Physical State:Solid
Solubility:Soluble in DMSO (≥20 mg/mL).
Storage:Store at -20° C
Melting Point:135-137 °C (dec.)
Boiling Point:566.97 °C
Density:1.38 g/cm3 (Predicted)
Refractive Index:n20D 1.58
IC50:MMP-2: IC50 = 0.7 nM (mouse); MMP-13: IC50 = 0.9 nM (mouse); MMP-9: IC50 = 13 nM (mouse); MMP-3: IC50 = 16 nM (mouse); MMP-1: IC50 = 1170 nM (mouse)
Safety and Reference Information
WGK Germany:1
PubChem CID:9907286
MDL Number:MFCD16618408
SMILES:CC(C)(C(=O)NO)NS(=O)(=O)C1=CC=C(C=C1)OC2=CC=C(C=C2)F
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
References
1. Rohde, L.E., et al. 1999. Circulation. 99: 3063-3070. PMID: 10368126
2. Lindsey, M.L., et al. 2002. Circulation. 105: 753-758. PMID: 11839633
3. Fang. L., et al. 2007. J. Mol. Cell. Cardiol. 43: 535-544. PMID: 17689559
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