Molecular structure of CP 100356 hydrochloride, CAS Number: 142716-85-6
CP 100356 hydrochloride (CAS 142716-85-6)
Alternate Names:
4-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)-N-(3,4-dimethoxyphenethyl)-6,7-dimethoxyquinazolin-2-amine
Application:
CP 100356 hydrochloride is a high affinity Mdr-1 inhibitor
CAS Number:
142716-85-6
Purity:
≥98%
Molecular Weight:
597.1
Molecular Formula:
C31H36N4O6•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
CP 100356 hydrochloride has been reported to be a high affinity multi-drug resistance protein (Mdr-1/P-gp) inhibitor. This compound binds to the active site of Mdr-1 and inhibits the efflux of active compounds, enhancing their effectiveness by allowing them to remain in the cytoplasm. It is selective for P-gp over multidrug resistance-associated protein 2 (MRP2) at 15 µM, as well as the cytochrome P450 (CYP) isoforms CYP1A2, CYP2C9, CYP2C19, CYP2D6, and CYP3A4 (IC50s = >50 µM for all) and organic anion transporter 1B1 (OATP1B1; IC50 = ~66 µM), but does inhibit breast cancer resistance protein (BCRP; IC50 = 1.5 µM).
CP 100356 hydrochloride (CAS 142716-85-6) References
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- Calcium and P-glycoprotein independent synergism between schweinfurthins and verapamil. | Sheehy, RM., et al. 2015. Cancer Biol Ther. 16: 1259-68. PMID: 26046259
- Fgd5 is a Rac1-specific Rho GEF that is selectively inhibited by aurintricarboxylic acid. | Park, S., et al. 2021. Small GTPases. 12: 147-160. PMID: 31601145
- Potent, Novel SARS-CoV-2 PLpro Inhibitors Block Viral Replication in Monkey and Human Cell Cultures. | Shen, Z., et al. 2021. bioRxiv.. PMID: 33594371
- Improved SARS-CoV-2 Mpro inhibitors based on feline antiviral drug GC376: Structural enhancements, increased solubility, and micellar studies. | Vuong, W., et al. 2021. Eur J Med Chem. 222: 113584. PMID: 34118724
- Rational Design of Hybrid SARS-CoV-2 Main Protease Inhibitors Guided by the Superimposed Cocrystal Structures with the Peptidomimetic Inhibitors GC-376, Telaprevir, and Boceprevir. | Xia, Z., et al. 2021. ACS Pharmacol Transl Sci. 4: 1408-1421. PMID: 34414360
- CP100356 Hydrochloride, a P-Glycoprotein Inhibitor, Inhibits Lassa Virus Entry: Implication of a Candidate Pan-Mammarenavirus Entry Inhibitor. | Takenaga, T., et al. 2021. Viruses. 13: PMID: 34578344
- Discovery of SARS-CoV-2 main protease covalent inhibitors from a DNA-encoded library selection. | Ge, R., et al. 2022. SLAS Discov. 27: 79-85. PMID: 35063690
- Covalent narlaprevir- and boceprevir-derived hybrid inhibitors of SARS-CoV-2 main protease: room-temperature X-ray and neutron crystallography, binding thermodynamics, and antiviral activity. | Kneller, D., et al. 2022. Res Sq.. PMID: 35169792
- Natural Compounds Inhibit SARS-CoV-2 nsp13 Unwinding and ATPase Enzyme Activities. | Corona, A., et al. 2022. ACS Pharmacol Transl Sci. 5: 226-239. PMID: 35434533
- Covalent narlaprevir- and boceprevir-derived hybrid inhibitors of SARS-CoV-2 main protease. | Kneller, DW., et al. 2022. Nat Commun. 13: 2268. PMID: 35477935
- Fluorescence-Based Activity Screening Assay Reveals Small Molecule Inhibitors of Vaccinia Virus mRNA Decapping Enzyme D9. | Bednarczyk, M., et al. 2022. ACS Chem Biol. 17: 1460-1471. PMID: 35576528
- Proscillaridin A Sensitizes Human Colon Cancer Cells to TRAIL-Induced Cell Death. | Semba, M., et al. 2022. Int J Mol Sci. 23: PMID: 35805980
- Efficacy of Licensed Monoclonal Antibodies and Antiviral Agents against the SARS-CoV-2 Omicron Sublineages BA.1 and BA.2. | Fiaschi, L., et al. 2022. Viruses. 14: PMID: 35891355
Inhibitor of:
Mdr-1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CP 100356 hydrochloride, 10 mg | sc-361154 | 10 mg | $377.00 | |||
CP 100356 hydrochloride, 50 mg | sc-361154A | 50 mg | $1122.00 |