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Ubiquitin Isopeptidase Inhibitor I, G5 (CAS 108477-18-5)

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Synonym:3,5-bis((4-Nitrophenyl)methylene)-1,1-dioxide, tetrahydro-4H-thiopyran-4-one
Application:A cell-permeable cross-conjugated unsaturated dienone compound
CAS Number:108477-18-5
Molecular Weight:414.4
Molecular Formula:C19H14N2O7S
Refer to Certificate of Analysis for lot specific data (including water content).
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Ubiquitin Isopeptidase Inhibitor I, G5 sc-356181 10 mg $240
Ubiquitin Isopeptidase Inhibitor I, G5 is a cell-permeable cross-conjugated α,β-unsaturated dienone compound reported to induce caspase activation and apoptosis via the apoptosome-independent mitochondrial pathway by selectively inhibiting ubiquitin isopeptidase activity. The cellular expression of Bax and Bak is essential for G5-activated apoptosis, while Bcl-2 appears to protect cells against the effect of G5. G5 is reported to exhibit similar pharmacological effects as Ubiquitin Isopeptidase Inhibitor II, F6 but is reported to be more potent (sc-296678). Additionally, at higher concentrations, it has been shown to induce necrosis in apoptosis-resistant MEFs-DKO.
Technical Information
Physical State:Solid
Solubility:Solubility: DMSO
Storage:Store at 4° C
Safety and Reference Information
PubChem CID:5918438
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

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1. Aleo, E., et al. 2006. Cancer Res. 66: 9235-9244. PMID: 16982768
2. Fontanini, A., et al. 2009. J. Biol. Chem. 284: 8369-8381. PMID: 19139105
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