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DAG Kinase Inhibitor II (CAS 120166-69-0)

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Synonym:Diacylglycerol Kinase Inhibitor II; R59949; 3-{2-[4-[bis-(4-Fluorophenyl)methylene]-1-piperidinyl]ethyl}-2,3-dihydro-2-thioxo-4(1H)quinazolinone
Application:An inhibitor of DGK
CAS Number:120166-69-0
Molecular Weight:489.6
Molecular Formula:C28H25F2N3OS
Refer to Certificate of Analysis for lot specific data (including water content).
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DAG Kinase Inhibitor II sc-3551 5 mg $101
DAG Kinase Inhibitor is an inhibitor of DGK (Diacylglycerol kinase; DAG Kinase) and is useful for elucidating the roles of protein kinase C (PKC). DAG Kinase Inhibitor has also been reported to inhibit DGK in several systems such as isolated platelet membranes, whole platelets and ghost erythrocytes. Additional reports have shown to inhibit in a concentration dependent manner. DAG Kinase Inhibitor may also inhibit other pathways such as NADPH and potentially interfere with the lipid-mediated assembly process of oxidase components as reported using a cell-free system. This particular isoform, R59949, has been reported to potentially exhibit selective inhibition of DGK-α.
Technical Information
Physical State:Solid
Solubility:Soluble in N,N-DMF (89 g/l), DMSO (33 g/l), dichloromethane (35 g/l), ethanol, ethyl acetate, 0.1 M HCl (slightly soluble), 0.1 M NaOH (slightly soluble), and tetrahydro-furan. Insoluble in water.
Storage:Store at 4° C
Melting Point:228-230° C
Boiling Point:637.07° C at 760 mmHg (Predicted)
Density:1.37 g/cm3 (Predicted)
Refractive Index:n20D 1.69 (Predicted)
IC50:diacylglycerol kinase in isolated platelet membranes: IC50 = 300 nM; diacylglycerol kinase in intact platelets: IC50 = 120 nM
pK Values:pKa: 11.24 (Predicted), pKb: 8.33 (Predicted)
Safety and Reference Information
WGK Germany:3
PubChem CID:657356
MDL Number:MFCD00069258
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

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1. de Chaffoy de Courcelles, D., et al. 1989. J. Biol. Chem. 264: 3274-3285. PMID: 2536741
2. Rodríguez-Liñares, B., et al. 1991. Biochem. Pharmacol. 41: 835-838. PMID: 1847818
3. Jones, D.R., et al. 1999. J. Biol. Chem. 274: 16846-16852. PMID: 10358029
4. Jiang, Y., et al. 2000. Biochem. Pharmacol. 59: 763-772. PMID: 10718334
5. Palicz, A., et al. 2001. J. Biol. Chem. 276: 3090-3097. PMID: 11060300
6. Outram, S.V., et al. 2002. Immunology. 105: 391-398. PMID: 11985659
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