Solubility: Soluble in DMSO (25 mg/ml) and ethanol (8 mg/ml warm)
SMILES: C1=C(C2=C(N1C3C(C(C(O3)CO)O)O)N=CN=C2N)I
Description
5-Iodotubercidin (Itu) has been shown to inhibit mitogen-activated protein kinase (ERK2) (Ki= 525 nM), adenosine kinase (ADK) (Ki= 30 nM), casein kinases 1 & 2 (CSNK1A1 & CSNK2A1), and insulin receptor kinase (IC50 ranging from 0.4-28 μM). Itu has been suggested to be a general protein kinase inhibitor.
Storage
Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.
For Research Use Only
The pharmacological and toxicological properties of this product have not been fully investigated. Exercise caution in use and handling. This product must not be used in humans.
1. Fox, T., et al. 1998. Protein Sci. 7: 2249-2255. PMID: 9827991
2. Massillon, D., et al. 1994. Biochem. J. 299: 123-128. PMID: 8166629
3. Flückiger-Isler, R.E. and Walter, P. 1993. Biochem. J. 292: 85-91. PMID: 8503865
