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Mitomycin C (CAS 50-07-7)

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Alternate Names:
Mitomycin C also known as Mitocin-C; Ametycine; Mutamycin; Mitomycin C from Streptomyces caespitosus ;7-amino-9-alpha-methoxymitosane azirino(2,3:3,4)pyrrolo(1,2-a)indole-4,7-dione,6-amino-8-(((aminocarbonyl)oxy azirino[2,3:3,4]pyrrolo[1,2-a]indole-4,7-dione,6-amino-8-[[(aminocarbonyl)ox mitomycine
Application:
Mitomycin C is a DNA crosslinking agent that inhibits DNA synthesis, induces apoptosis in a variety of cells, and activates caspase
CAS Number:
50-07-7
Purity:
≥99%
Molecular Weight:
334.33
Molecular Formula:
C15H18N4O5
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Mitomycin C is part of a family of azidine natural products. Mitomycin C is produced by a strain actinomyces, Streptomyces caespitosus. Mitomycin C is a DNA crosslinking and damaging agent, making it a useful antibiotic and antitumor compound. When crosslinking, Mitomycin C displays absolute specificity and high efficiency for the CpG sequence. Mammalian Cells treated with Mitomycin C (0.4 mg/mL for 5 min) can undergo apoptosis through upregulation of Bad, Fas, FasL and phosphorylated p53 along with activation of caspase-3, caspase-8, and caspase-9 activating both the intrinsic and extrinsic pathway for apoptosis.

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA

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Mitomycin C (CAS 50-07-7) References

  1. Synthesis of Mitomycin C and Decarbamoylmitomycin C N(2) deoxyguanosine-adducts.  |  Champeil, E., et al. 2016. Bioorg Chem. 65: 90-9. PMID: 26894558
  2. Diminishing the side effect of mitomycin C by using pH-sensitive liposomes: in vitro characterization and in vivo pharmacokinetics.  |  Fang, YP., et al. 2018. Drug Des Devel Ther. 12: 159-169. PMID: 29391780
  3. Isolation and structure of a covalent cross-link adduct between mitomycin C and DNA.  |  Tomasz, M., et al. 1987. Science. 235: 1204-8. PMID: 3103215
  4. Mechanism of monofunctional and bifunctional alkylation of DNA by mitomycin C.  |  Tomasz, M., et al. 1988. Biochemistry. 27: 3182-7. PMID: 3134045
  5. Mitomycin C-induced cell cycle arrest enhances 5-aminolevulinic acid-based photodynamic therapy for bladder cancer.  |  Nakayama, T., et al. 2020. Photodiagnosis Photodyn Ther. 31: 101893. PMID: 32592910
  6. [Transcription of DNA-Methyltransferases in Endothelial Cells Exposed to Mitomycin C].  |  Sinitsky, MY., et al. 2022. Mol Biol (Mosk). 56: 491-497. PMID: 35621104
  7. Establishment of two canine models of benign airway stenosis and the effect of mitomycin C on airway stenosis.  |  Li, F., et al. 2022. Int J Pediatr Otorhinolaryngol. 159: 111205. PMID: 35700689
  8. Mitomycin C suppresses aqueous human flow in cynomolgus monkeys.  |  Kee, C., et al. 1995. Arch Ophthalmol. 113: 239-42. PMID: 7864759
  9. p53-dependent and p53-independent activation of apoptosis in mammary epithelial cells reveals a survival function of EGF and insulin.  |  Merlo, GR., et al. 1995. J Cell Biol. 128: 1185-96. PMID: 7896881
  10. DT-diaphorase in activation and detoxification of quinones. Bioreductive activation of mitomycin C.  |  Ross, D., et al. 1993. Cancer Metastasis Rev. 12: 83-101. PMID: 8375023
  11. Poly(ADP-ribosyl)ation of histone H1 correlates with internucleosomal DNA fragmentation during apoptosis.  |  Yoon, YS., et al. 1996. J Biol Chem. 271: 9129-34. PMID: 8621564
  12. Mitomycin C dissolved in a reversible thermosetting gel: target tissue concentrations in the rabbit eye.  |  Ichien, K., et al. 1997. Br J Ophthalmol. 81: 72-5. PMID: 9135413
  13. Transconjunctival mitomycin C as an adjunct to conventional glaucoma filtration surgery in rabbits.  |  Buffenn, AN., et al. 1997. J Glaucoma. 6: 314-8. PMID: 9327350
  14. Mitomycin C: small, fast and deadly (but very selective).  |  Tomasz, M. 1995. Chem Biol. 2: 575-9. PMID: 9383461

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Mitomycin C, 2 mg

sc-3514A
2 mg
$66.00

Mitomycin C, 5 mg

sc-3514
5 mg
$101.00

Mitomycin C, 10 mg

sc-3514B
10 mg
$143.00